Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.70 extracted from

  • Bartoli, D.; Piobbico, D.; Bellet, M.M.; Bennati, A.M.; Roberti, R.; Della Fazia, M.A.; Servillo, G.
    Impaired cell proliferation in regenerating liver of 3beta-hydroxysterol DELTA14-reductase (TM7SF2) knock-out mice (2016), Cell Cycle, 15, 2164-2173 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.70

Protein Variants

Protein Variants Comment Organism
additional information generation of gene Tm7sf2 knockout mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Mus musculus 5783
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q71KT5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
3 beta-hydroxysterol-DELTA14-reductase
-
 Mus musculus
3beta-hydroxysterol DELTA14-reductase
-
 Mus musculus
C14-SR
-
 Mus musculus
TM7SF2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Tm7sf2 deficiency during liver regeneration alters lipid metabolism and generates a stress condition, which, in turn, transiently unbalances hepatocytes cell cycle progression. Tm7sf2 knockout mice show no alteration in cholesterol content, but accumulation and delayed catabolism of hepatic triglycerides is observed, resulting in persistent steatosis at all times post hepatectomy. Delayed cell cycle progression to the G1/S phase is observed in Tm7sf2 knockout mice, resulting in reduced cell division at the time points examined associated to abnormal endoplasmic reticulum stress response, leading to alteration in p53 content and, consequently, induction of p21 expression in Tm7sf2 knockout mice. Tm7sf2 knockout mice exhibit a high-degree of transient hepatic steatosis during liver regeneration after partial hepatectomy. Hepatocytes from Tm7sf2 KO mice have a defective progression through the G1/S phase, associated to delayed and/or reduced expression of central regulators of the cell cycle such as cyclin D1, cyclin A, cyclin E1 and CDK4 Mus musculus
physiological function the enzyme catalyzes the reduction of C14-unsaturated sterols during cholesterol biosynthesis from lanosterol. Role of C14-SR in vivo during cell proliferation by evaluating liver regeneration in Tm7sf2 knockout and wild-type mice, overview Mus musculus