Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-5-ol | - |
Echinococcus multilocularis | |
N-(4-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-6-yl)prop-2-enamide | - |
Echinococcus multilocularis | |
N-[2-(4-tert-butylphenyl)ethyl]-5-(1-methylethoxy)phthalazin-1-amine | - |
Echinococcus multilocularis | |
N-[2-(4-tert-butylphenyl)ethyl]-5-methoxyphthalazin-1-amine | - |
Echinococcus multilocularis | |
N-[2-(4-tert-butylphenyl)ethyl]phthalazin-1-amine | quinazoline | Echinococcus multilocularis | |
N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,6-diamine | - |
Echinococcus multilocularis | |
N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,7-diamine | - |
Echinococcus multilocularis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Echinococcus multilocularis | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Echinococcus multilocularis | - |
- |
- |
Echinococcus multilocularis Nemuro | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
protoscolex | - |
Echinococcus multilocularis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.045 | - |
in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl, at 25°C | Echinococcus multilocularis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + NADH + H+ | - |
Echinococcus multilocularis | succinate + NAD+ | - |
? | |
fumarate + NADH + H+ | - |
Echinococcus multilocularis Nemuro | succinate + NAD+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Echinococcus multilocularis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0021 | - |
in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C | Echinococcus multilocularis | N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,7-diamine | |
0.0023 | - |
in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C | Echinococcus multilocularis | N-[2-(4-tert-butylphenyl)ethyl]phthalazin-1-amine | |
0.016 | - |
in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C | Echinococcus multilocularis | N-(4-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-6-yl)prop-2-enamide | |
0.048 | - |
in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C | Echinococcus multilocularis | N-[2-(4-tert-butylphenyl)ethyl]-5-methoxyphthalazin-1-amine | |
0.062 | - |
in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C | Echinococcus multilocularis | N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,6-diamine | |
0.071 | - |
in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C | Echinococcus multilocularis | 1-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-5-ol | |
0.91 | - |
in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C | Echinococcus multilocularis | N-[2-(4-tert-butylphenyl)ethyl]-5-(1-methylethoxy)phthalazin-1-amine | |
4.1 | - |
in 30 mM potassium phosphate (pH 7.4) and 1 mM MgCl2, at 25°C | Echinococcus multilocularis | N-[2-(4-tert-butylphenyl)ethyl]-5-methoxyphthalazin-1-amine |