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Literature summary for 1.3.1.6 extracted from

  • Besteiro, S.; Biran, M.; Biteau, N.; Coustou, V.; Baltz, T.; Canioni, P.; Bringaud, F.
    Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme: NADH-dependent fumarate reductase (2002), J. Biol. Chem., 22, 38001-38012.
No PubMed abstract available
Search for more literature for 1.3.1.6

Cloned(Commentary)

Cloned (Comment) Organism
delta FDRg2, fumarate reductase deficiency mutant Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
glyoxysome soluble at high ionic strength Trypanosoma brucei 9514
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
-
 Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fumarate + NADH + H+ Trypanosoma brucei involved in energy metabolism by maintaining the NAD+/NADH balance in glyoxysomes, main source of succinate production succinate + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei Q8ITL2
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.142
-
 glyoxysomal fraction Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fumarate + NADH + H+
-
 Trypanosoma brucei succinate + NAD+
-
 ?
fumarate + NADH + H+ involved in energy metabolism by maintaining the NAD+/NADH balance in glyoxysomes, main source of succinate production Trypanosoma brucei succinate + NAD+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Trypanosoma brucei