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Literature summary for 1.3.1.6 extracted from
- Properties and function of fumarate reductase (NADH) in Streptococcus lactis (1979), Aust. J. Biol. Sci., 32, 625-635.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cinnamic acid | preincubation | Lactococcus lactis |  |
| citraconate | - |
Enterococcus faecalis | |
| citraconate | preincubation | Lactococcus lactis | |
| mesaconic acid | strong inhibition with and without preincubation | Lactococcus lactis | |
| succinate | - |
Enterococcus faecalis | |
| succinate | preincubation | Lactococcus lactis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fumarate + NADH + H+ | Lactococcus lactis | - |
succinate + NAD+ | - |
? | |
| fumarate + NADH + H+ | Enterococcus faecalis | may replace oxygen as terminal elecron acceptor | succinate + NAD+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecalis | - |
- |
- |
| Lactococcus lactis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Lactococcus lactis |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.7 | - |
partially purified enzyme | Lactococcus lactis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acrylic acid + NADH | poor substrate | Lactococcus lactis | propanoic acid + NAD+ | - |
? | |
| cinnamic acid + NADH + H+ | poor substrate | Lactococcus lactis | 3-phenylpropanoic acid + NAD+ | - |
? | |
| citraconic acid + NADH | very poor substrate | Lactococcus lactis | 2-methylbutanedioic acid + NAD+ | - |
? | |
| fumarate + NADH + H+ | - |
Lactococcus lactis | succinate + NAD+ | - |
? | |
| fumarate + NADH + H+ | - |
Enterococcus faecalis | succinate + NAD+ | - |
ir | |
| fumarate + NADH + H+ | strain C10 only active with FADH2 or FMNH2 | Lactococcus lactis | succinate + NAD+ | - |
ir | |
| fumarate + NADH + H+ | may replace oxygen as terminal elecron acceptor | Enterococcus faecalis | succinate + NAD+ | - |
? | |
| maleate + NADH | - |
Enterococcus faecalis | succinate + NAD+ | - |
ir | |
| maleate + NADH | 90% as effective as furmarate | Lactococcus lactis | succinate + NAD+ | - |
ir | |
| mesaconate + NADH | - |
Enterococcus faecalis | methylsuccinate + NAD+ | - |
? | |
| mesaconate + NADH | very poor substrate | Lactococcus lactis | methylsuccinate + NAD+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Lactococcus lactis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 7.5 | - |
Lactococcus lactis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FADH2 | non covalently bound | Lactococcus lactis | |
| FMNH2 | - |
Lactococcus lactis | |
| FMNH2 | - |
Enterococcus faecalis | |
| NADH | - |
Lactococcus lactis | |
| NADH | - |
Enterococcus faecalis | |
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