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Literature summary for 1.3.1.48 extracted from

  • Dick, R.A.; Kwak, M.K.; Sutter, T.R.; Kensler, T.W.
    Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase (2001), J. Biol. Chem., 276, 40803-40810.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
15-ketoprostaglandin E1
-
Rattus norvegicus
0.016
-
3-nonen-2-one
-
Rattus norvegicus
0.039
-
benzylidene acetone
-
Rattus norvegicus
0.04
-
trans-2-decenal
-
Rattus norvegicus
0.046
-
trans-2-nonenal
-
Rattus norvegicus
0.06
-
trans-2-dodecenal
-
Rattus norvegicus
0.075
-
cinnamaldehyde
-
Rattus norvegicus
0.11
-
ethylvinylketone
-
Rattus norvegicus
0.12
-
4-hydroxy-2-nonenal
-
Rattus norvegicus
0.15
-
acrolein
-
Rattus norvegicus
0.18
-
chalcone
-
Rattus norvegicus
0.21
-
4-hydroxy-2-hexenal
-
Rattus norvegicus
0.36
-
trans-2-octenal
-
Rattus norvegicus
0.41
-
trans,trans-2,4-nonadienal
-
Rattus norvegicus
0.49
-
3-penten-2-one
-
Rattus norvegicus
0.58
-
methylvinylketone
-
Rattus norvegicus
1
-
trans-2-hexenal
-
Rattus norvegicus
1.7
-
alpha-methylcinnamaldehyde
-
Rattus norvegicus
2.4
-
trans-2-pentenal
-
Rattus norvegicus
3.9
-
crotonaldehyde
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NAD(P)H
-
Rattus norvegicus (5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+
-
?
15-ketoprostaglandin E1 + NADH + H+
-
Rattus norvegicus 13,14-dihydro-15-ketoprostaglandin E1 + NAD+
-
r
3-nonen-2-one + NADPH
-
Rattus norvegicus nonane-2-one + NADP+
-
?
3-penten-2-one + NADPH
-
Rattus norvegicus pentane-2-one + NADP+
-
?
4-hydroxy-2-hexenal + NADPH
-
Rattus norvegicus 4-hydroxyhexanal + NADP+
-
?
4-hydroxy-2-nonenal + NADPH
-
Rattus norvegicus 4-hydroxynonanal + NADP+
-
?
acrolein + NADPH
-
Rattus norvegicus propanal + NADP+
-
?
alpha-methylcinnamaldehyde + NADPH
-
Rattus norvegicus ?
-
?
chalcone + NADPH
-
Rattus norvegicus ?
-
?
ethylvinylketone + NADPH
-
Rattus norvegicus pentane-3-one + NADP+
-
?
trans,trans-2,4-nonadienal + NADPH + H+
-
Rattus norvegicus ?
-
r
trans-2-butenal + NAD(P)H
-
Rattus norvegicus butanal + NAD(P)+
-
?
trans-2-decenal + NADPH
-
Rattus norvegicus decanal + NADP+
-
?
trans-2-dodecenal + NADPH
-
Rattus norvegicus dodecanal + NADP+
-
?
trans-2-hexenal + NAD(P)H
-
Rattus norvegicus hexanal + NAD(P)+
-
?
trans-2-nonenal + NADPH
-
Rattus norvegicus nonanal + NADP+
-
?
trans-2-octenal + NADPH
-
Rattus norvegicus octanal + NADP+
-
?
trans-2-pentenal + NADPH
-
Rattus norvegicus pentanal + NADP+
-
?
trans-benzylideneacetone + NAD(P)H
-
Rattus norvegicus benzylacetone + NAD(P)+
-
?
trans-cinnamaldehyde + NAD(P)H
-
Rattus norvegicus ?
-
?
trans-methylvinylketone + NAD(P)H
-
Rattus norvegicus butane-2-one + NAD(P)+
-
?
trans-trans-2,4-hexadienal + NAD(P)H
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
NAD(P)H-dependent alkenal/one oxidoreductase
-
Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.72
-
acrolein
-
Rattus norvegicus
8.05
-
crotonaldehyde
-
Rattus norvegicus
13.1
-
alpha-methylcinnamaldehyde
-
Rattus norvegicus
13.4
-
4-hydroxy-2-hexenal
-
Rattus norvegicus
15.7
-
cinnamaldehyde
-
Rattus norvegicus
16.8
-
trans-2-pentenal
-
Rattus norvegicus
17.2
-
trans,trans-2,4-nonadienal
-
Rattus norvegicus
18.5
-
3-penten-2-one
-
Rattus norvegicus
19.8
-
3-nonen-2-one
-
Rattus norvegicus
28.8
-
trans-2-hexenal
-
Rattus norvegicus
32.3
-
chalcone
-
Rattus norvegicus
40
-
15-ketoprostaglandin E1
-
Rattus norvegicus
54.7
-
benzylidene acetone
-
Rattus norvegicus
60.2
-
trans-2-dodecenal
-
Rattus norvegicus
67.3
-
4-hydroxy-2-nonenal
-
Rattus norvegicus
70.8
-
trans-2-decenal
-
Rattus norvegicus
89.7
-
trans-2-octenal
-
Rattus norvegicus
94.5
-
trans-2-nonenal
-
Rattus norvegicus
156
-
methylvinylketone
-
Rattus norvegicus
160
-
ethylvinylketone
-
Rattus norvegicus