Literature summary for 1.3.1.39 extracted from

Kwon, Y.J.; Sohn, M.J.; Oh, T.; Cho, S.N.; Kim, C.J.; Kim, W.G.
Panosialins, inhibitors of enoyl-ACP reductase from Streptomyces sp. AN1761 (2013), J. Microbiol. Biotechnol., 23, 184-188.

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Inhibitors

Inhibitors	Comment	Organism	Structure
panosialin A	acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis	Staphylococcus aureus
panosialin B	acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis	Staphylococcus aureus
panosialin wA	acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis	Staphylococcus aureus
panosialin wB	acylbenzenediol sulfate metabolites from Streptomyces sp. AN1761, potently inhibits bacterial enoyl-ACP reductases of Staphylococcus aureus, Streptococcus pneumoniae, and Mycobacterium tuberculosis	Staphylococcus aureus
triclosan	-	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	Q6GI75	-	-

Synonyms

Synonyms	Comment	Organism
FabI	-	Staphylococcus aureus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00066	-	pH 6.5, temperature not specified in the publication	Staphylococcus aureus	triclosan
0.003	-	pH 6.5, temperature not specified in the publication	Staphylococcus aureus	panosialin wA
0.0043	-	pH 6.5, temperature not specified in the publication	Staphylococcus aureus	panosialin A
0.0046	-	pH 6.5, temperature not specified in the publication	Staphylococcus aureus	panosialin wB
0.0053	-	pH 6.5, temperature not specified in the publication	Staphylococcus aureus	panosialin B

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Release 2023.1 (January 2023)