BRENDA - Enzyme Database
show all sequences of 1.3.1.3

Towards the elucidation of the ecdysteroid biosynthetic pathway

Dauphin-Villemant, C.; Blais, C.; Lafont, R.; Ann. N. Y. Acad. Sci. 839, 306-310 (1998)
No PubMed abstract available

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Pancrustacea
5829
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Pancrustacea
enzyme is involved in the biosynthesis of ecdysteroids, catalyzes the 5beta-reduction of a 3-oxo-DELTA4-diketol to a 3-oxo-5beta-diketol
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pancrustacea
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
molting gland
specifically in crustaceans
Pancrustacea
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
enzyme is involved in the biosynthesis of ecdysteroids, catalyzes the 5beta-reduction of a 3-oxo-DELTA4-diketol to a 3-oxo-5beta-diketol
390598
Pancrustacea
?
-
-
-
-
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Pancrustacea
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Pancrustacea
enzyme is involved in the biosynthesis of ecdysteroids, catalyzes the 5beta-reduction of a 3-oxo-DELTA4-diketol to a 3-oxo-5beta-diketol
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
molting gland
specifically in crustaceans
Pancrustacea
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
enzyme is involved in the biosynthesis of ecdysteroids, catalyzes the 5beta-reduction of a 3-oxo-DELTA4-diketol to a 3-oxo-5beta-diketol
390598
Pancrustacea
?
-
-
-
-
Other publictions for EC 1.3.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
726120
Bauer
Vein patterning 1-encoded prog ...
Arabidopsis thaliana, Digitalis lanata
Phytochemistry
77
53-59
2012
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2
1
15
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2
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1
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2
1
15
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12
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1
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4
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2
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12
2
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4
4
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12
12
724713
Mindnich
The effect of disease associat ...
Homo sapiens
Chem. Biol. Interact.
191
250-254
2011
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1
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5
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3
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726492
Chen
Substrate specificity and inhi ...
Homo sapiens
Steroids
76
484-490
2011
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11
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1
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2
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11
725399
Drury
Characterization of disease-re ...
Homo sapiens
J. Biol. Chem.
285
24529-24537
2010
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5
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1
5
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5
1
1
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8
1
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1
1
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8
8
725633
McNeilly
Bile acids modulate glucocorti ...
Rattus norvegicus
J. Hepatol.
52
705-711
2010
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1
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1
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1
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697264
Di Costanzo
Aldo-keto reductases in which ...
Digitalis lanata
Chem. Biol. Interact.
178
127-133
2009
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1
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4
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4
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704908
Ueki
SRD5B1 gene analysis needed fo ...
Homo sapiens
J. Gastroenterol. Hepatol.
24
776-785
2009
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705710
Di Costanzo
Structure and catalytic mechan ...
Homo sapiens
Mol. Cell. Endocrinol.
301
191-198
2009
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1
1
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2
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1
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5
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685271
Faucher
The crystal structure of human ...
Homo sapiens
Biochemistry
47
8261-8270
2008
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1
1
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1
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1
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3
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687723
Di Costanzo
Crystal structure of human liv ...
Homo sapiens
J. Biol. Chem.
283
16830-16839
2008
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1
1
2
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1
1
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3
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698762
Thorn
The crystal structure of proge ...
Digitalis lanata
J. Biol. Chem.
283
17260-17269
2008
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1
1
2
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1
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4
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1
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702225
Faucher
Crystal structures of human De ...
Homo sapiens
Biochemistry
47
13537-13546
2008
-
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1
1
2
-
3
4
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3
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1
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5
1
1
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3
1
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1
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5
1
1
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3
1
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3
3
706774
Palermo
Human Delta4-3-oxosteroid 5bet ...
Homo sapiens
Steroids
73
417-423
2008
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1
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1
1
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671346
Gavidia
Plant progesterone 5beta-reduc ...
Digitalis purpurea
Phytochemistry
68
853-864
2007
-
1
1
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2
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2
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6
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1
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5
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1
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1
1
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1
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5
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1
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671101
Egerer-Sieber
Crystallization and preliminar ...
Digitalis lanata
Acta Crystallogr. Sect. F
62
186-188
2006
-
1
1
1
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4
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1
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676376
Herl
Molecular cloning and heterolo ...
Digitalis lanata
Phytochemistry
67
225-231
2006
-
1
1
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5
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1
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6
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1
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1
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6
1
1
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1
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1
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1
1
1
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5
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1
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1
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6
1
1
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1
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676735
Herl
Molecular cloning and expressi ...
Isoplexis canariensis
Planta Med.
72
1163-1165
2006
-
1
1
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5
-
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1
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6
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1
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1
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4
1
1
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1
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1
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1
1
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5
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1
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1
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4
1
1
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1
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390597
Charbonneau
Genomic organization of a huma ...
Homo sapiens
Biochim. Biophys. Acta
1517
228-235
2001
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1
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6
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1
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1
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7
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1
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7
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390598
Dauphin-Villemant
-
Towards the elucidation of the ...
Pancrustacea
Ann. N. Y. Acad. Sci.
839
306-310
1998
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390650
Jez
Engineering steroid 5beta-redu ...
Rattus norvegicus
Biochemistry
37
9695-9703
1998
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2
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390590
Furuebisu
Identification of cortisone 5b ...
Rattus norvegicus
Biochim. Biophys. Acta
912
110-114
1987
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3
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390591
Okuda
Purification and characterizat ...
Rattus norvegicus
J. Biol. Chem.
259
7519-7524
1984
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2
1
8
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1
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2
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8
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1
1
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1
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8
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1
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2
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8
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7
1
1
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390592
Wilton
Is a Schiff base involved in t ...
Rattus norvegicus
Biochem. J.
155
487-491
1976
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390593
Collins
Subcellular localization and p ...
Mus musculus
Biochem. J.
147
165-174
1975
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390649
Ozon
Transformation of testosterone ...
Pelophylax esculentus
Biochim. Biophys. Acta
348
425-437
1974
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9
2
1
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1
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9
1
2
1
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1
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2
1
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1
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1
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1
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1
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2
3
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1
1
1
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6
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1
1
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1
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1
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1
-
2
3
-
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1
1
1
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Nduaguba
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1
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1
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1
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1
2
1
2
-
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1
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1
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1
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18
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1
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2
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1
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1
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1
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18
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1
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Tomkins
The enzymatic reduction of DEL ...
Bos taurus, Cavia porcellus, Columba sp., Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
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1
1
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6
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1
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1
1
1
6
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1
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Forchielli
Separation of DELTA4-5alpha- a ...
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