Literature summary for 1.3.1.22 extracted from

Han, Y.; Zhuang, Q.; Sun, B.; Lv, W.; Wang, S.; Xiao, Q.; Pang, B.; Zhou, Y.; Wang, F.; Chi, P.; Wang, Q.; Li, Z.; Zhu, L.; Li, F.; Deng, D.; Chiang, Y.; Li, Z.; Ren, R.
Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism (2021), Nat. Commun., 12, 449 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structure of SRD5A in complex with NADPH at 2.0 A resolution. SRD5A exists as a monomer comprised of seven transmembrane segments (TMs). The TM1-4 enclose a hydrophobic substrate binding cavity, whereas TM5-7 coordinate cofactor NADPH through extensive hydrogen bonds network	Proteobacteria bacterium

Inhibitors

Inhibitors	Comment	Organism	Structure
dutasteride	-	Proteobacteria bacterium

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
27500	-	analytical ultracentrifugation	Proteobacteria bacterium

Organism

Organism	UniProt	Comment	Textmining
Proteobacteria bacterium	A0A3A0FWV3	-	-

Subunits

Subunits	Comment	Organism
monomer	1 * 29000, calculated from sequence	Proteobacteria bacterium

Synonyms

Synonyms	Comment	Organism
DCC71_03205	-	Proteobacteria bacterium

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0016	-	pH 7.4, 37°C	Proteobacteria bacterium	dutasteride

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Release 2023.1 (January 2023)