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Literature summary for 1.3.1.22 extracted from

  • Hosoda, S.; Hashimoto, Y.
    3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1 (2007), Bioorg. Med. Chem. Lett., 17, 5414-5418.
    View publication on PubMed
Search for more literature for 1.3.1.22

Inhibitors

Inhibitors Comment Organism Structure
4-(1-[4-[acetyl(methyl)amino]-3-methylphenyl]-1-ethylpropyl)-2-methylphenyl diethylcarbamate 22% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]-3-methylphenyl]-1-ethylpropyl)phenyl diethylcarbamate 25% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)-2-methylphenyl diethylcarbamate 56% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl 4-methylpiperazine-1-carboxylate 17% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl azepane-1-carboxylate 70% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl azocane-1-carboxylate 20% inhibition at 0.001 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl bis(1-methylethyl)carbamate 72% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl bis(1-methylpropyl)carbamate 22% inhibition at 0.001 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl dibenzylcarbamate 51% inhibition at 0.001 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl dibutylcarbamate 32% inhibition at 0.001 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl diethylcarbamate 57% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl dimethylcarbamate 29% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl dipropylcarbamate 77% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl morpholine-4-carboxylate 15% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl piperidine-1-carboxylate 68% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-ethylpropyl)phenyl pyrrolidine-1-carboxylate 57% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-methylethyl)phenyl diethylcarbamate 16% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]-1-propylbutyl)phenyl diethylcarbamate 27% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]cyclobutyl)phenyl diethylcarbamate 16% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]cycloheptyl)phenyl diethylcarbamate 25% inhibition at 0.01 mM; 46% inhibition at 0.01 mM Homo sapiens
4-(1-[4-[acetyl(methyl)amino]phenyl]cyclopentyl)phenyl diethylcarbamate 5% inhibition at 0.01 mM Homo sapiens
4-(3-(4-(N-methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate competitive inhibitor Homo sapiens
4-[1-[4-(acetylamino)-3-methylphenyl]-1-ethylpropyl]-2-methylphenyl diethylcarbamate 17% inhibition at 0.01 mM Homo sapiens
dutasteride
-
 Homo sapiens
finasteride
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+ + H+
-
 ?

Synonyms

Synonyms Comment Organism
5alpha-reductase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00084
-
-
 Homo sapiens 4-(3-(4-(N-methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate