Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-methyl-4-azasteroids | 4-MA is a 90-fold more potent inhibitor than finasteride in the DU 145 cell-line; competitive | Homo sapiens | |
4-methyl-4-azasteroids | competitive | Spodoptera frugiperda | |
4-methyl-azasteroid | - |
Spodoptera frugiperda | |
finasteride | - |
Homo sapiens | |
finasteride | - |
Spodoptera frugiperda |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Spodoptera frugiperda | - |
Sf 9 cell-line | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate gland | studies in DU 145 cells, a human cell-line of low androgen sensitivity derived from a cerebral metastasis of an ephithelial prostate cancer | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androstenedione + NADPH + H+ | - |
Homo sapiens | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
deoxycorticosterone + NADPH | - |
Homo sapiens | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000084 | - |
4-methyl-azasteroid | - |
Spodoptera frugiperda | |
0.00033 | - |
finasteride | - |
Spodoptera frugiperda |