Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.22 extracted from

  • Wigley, W.C.; Prihoda, J.S.; Mowszowicz, I.; Mendonca, B.B.; New, M.I.; Wilson, J.D.; Russel, D.W.
    Natural mutagenesis study of the human steroid 5alpha-reductase 2 isozyme (1994), Biochemistry, 33, 1265-1270.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
G183S mutant of 5alpha-reductase isozyme type-2 Homo sapiens
G196S mutant of 5alpha-reductase isozyme type-2 Homo sapiens
G34R mutant of 5alpha-reductase isozyme type-2 Homo sapiens
H231R mutant of 5alpha-reductase isozyme type-2 Homo sapiens
H264Q mutant of 5alpha-reductase isozyme type-2 Homo sapiens
N193S mutant of 5alpha-reductase isozyme type-2 Homo sapiens
P181L mutant of 5alpha-reductase isozyme type-2 Homo sapiens
R145W mutant of 5alpha-reductase isozyme type-2 Homo sapiens
R171S mutant of 5alpha-reductase isozyme type-2 Homo sapiens
R246W mutant of 5alpha-reductase isozyme type-2 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
testosterone enzyme mutant R246Q Homo sapiens
0.001
-
testosterone
-
Homo sapiens
0.001
-
testosterone enzyme mutant G196S Homo sapiens
0.001
-
testosterone enzyme mutant R246W Homo sapiens
0.0012
-
testosterone enzyme mutant R145W Homo sapiens
0.0012
-
testosterone enzyme mutant N193S Homo sapiens
0.0018
-
testosterone enzyme mutant G183S Homo sapiens
0.0022
-
testosterone enzyme mutant P181L Homo sapiens
0.0023
-
testosterone enzyme mutant R171S Homo sapiens
0.012
-
testosterone enzyme mutant G34R Homo sapiens
0.014
-
testosterone enzyme mutant H231R Homo sapiens
0.015
-
NADPH enzyme mutant G34R Homo sapiens
0.02
-
NADPH
-
Homo sapiens
0.025
-
NADPH enzyme mutant H231R Homo sapiens
0.18
-
NADPH enzyme mutant G196S Homo sapiens
0.316
-
NADPH enzyme mutant G183S Homo sapiens
0.325
-
NADPH enzyme mutant N193S Homo sapiens
0.34
-
NADPH enzyme mutant R171S Homo sapiens
0.401
-
NADPH enzyme mutant R246Q Homo sapiens
0.526
-
NADPH enzyme mutant P181L Homo sapiens
0.584
-
NADPH enzyme mutant R145W Homo sapiens
0.65
-
NADPH enzyme mutant R246W Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + NADPH + H+
-
Homo sapiens 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
Homo sapiens
5.2 5.6 mutant G34R Homo sapiens
6 6.5 mutant P181L Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens