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Literature summary for 1.3.1.22 extracted from

  • Scheer, H.; Robaire, B.
    Solubilization and partial characterization of rat epididymal delta 4-steroid 5alpha-reductase (cholestenone 5alpha-reductase) (1983), Biochem. J., 211, 65-74.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
17alpha-hydroxyprogesterone
-
Rattus norvegicus
androst-4-enedione
-
Rattus norvegicus
NADP+
-
Rattus norvegicus
progesterone competitive Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
testosterone nuclear and microsomal solubilized enzyme Rattus norvegicus
0.00102
-
NADPH nuclear enzyme Rattus norvegicus
0.0376
-
NADPH microsomal membrane-bound enzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
nucleus
-
Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymis
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-20°C, 1 week, solubilized enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholest-4-en-3-one + NADPH
-
Rattus norvegicus 5-alpha-cholestan-3-one + NADP+
-
?
testosterone + NADPH + H+
-
Rattus norvegicus 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.8 7.5
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5 8.5 at pH 5 and 8.5: about 50% of activity maximum Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus