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Literature summary for 1.3.1.22 extracted from
- Studies on the mechanism of the DELTA-4-3-oxosteroid-5alpha-reduction in rat liver microsomes (1974), Hoppe-Seyler's Z. Physiol. Chem., 355, 1499-1507.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| testosterone + NADPH + H+ | reversible in the presence of coenzyme Q10 as electron-acceptor, electrons are transferred from NADPH to coenzyme Q10 via the enzyme NADPH:coenzyme Q10-oxidoreductase and then to testosterone | Rattus norvegicus | androstan-3alpha,17beta-diol + androstan-3beta,17beta-diol + 5alpha-dihydrotestosterone | - |
r |  |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| coenzyme Q10 | - |
Rattus norvegicus | |
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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