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Literature summary for 1.3.1.21 extracted from

  • Tuckey, R.; Tang, E.; Chen, Y.; Slominski, A.
    Selective ability of rat 7-dehydrocholesterol reductase (DHCR7) to act on some 7-dehydrocholesterol metabolites but not on lumisterol metabolites (2021), J. Steroid Biochem. Mol. Biol., 212, 105929 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
20S-hydroxy-7-dehydrocholesterol inhibits the conversion of ergosterol to brassicasterol similarly to 7-dehydrocholesterol Rattus norvegicus
20S-hydroxylumisterol
-
 Rattus norvegicus
22-hydroxy-lumisterol
-
 Rattus norvegicus
27-hydroxydehydrocholesterol inhibits the conversion of ergosterol by 25% Rattus norvegicus
7-dehydrocholesterol 0.03 mM, inhibits the conversion of ergosterol to brassicasterol by 93% Rattus norvegicus
8-dehydrocholesterol
-
 Rattus norvegicus
additional information not inhibitory: 7-dehydropregnenolone, 25(OH)7-dehydrocholesterol, L3 or vitamin D3 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.28
-
 NADPH substrate ergosterol, pH 7.5, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9Z2Z8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
20,22-hydroxylumisterol-3 + NADPH + H+
-
 Rattus norvegicus ? + NADP+
-
 ?
20S-hydroxy-7-dehydrocholesterol + NADPH + H+
-
 Rattus norvegicus 20S-hdroxycholesterol + NADP+
-
 ?
22-hydroxylumisterol-3 + NADPH + H+
-
 Rattus norvegicus ? + NADP+
-
 ?
27-hydroxydehydrocholesterol + NADPH + H+
-
 Rattus norvegicus 27-hydroxycholesterol + NADP+
-
 ?
7-dehydrodesmosterol + NADPH + H+
-
 Rattus norvegicus desmosterol + NADP+
-
 ?
7-hydroxycholesterol + NADPH + H+
-
 Rattus norvegicus cholesterol + NADP+
-
 ?
ergosterol + NADPH + H+
-
 Rattus norvegicus brassicasterol + NADP+
-
 ?
lumisterol-3 + NADPH + H+
-
 Rattus norvegicus ? + NADP+
-
 ?
additional information no substrates: 8-dehydrocholesterol or 20S-hydroxylumisterol Rattus norvegicus ?
-
-

Synonyms

Synonyms Comment Organism
Dhcr7
-
 Rattus norvegicus