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Literature summary for 1.3.1.21 extracted from
- The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally (2015), J. Lipid Res., 56, 888-897.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in CHO-EV and CHO-DHCR24-V5 cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + NADP+ | Homo sapiens | - |
cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + NADP+ | - |
Homo sapiens | cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Dhcr7 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is important for both cholesterol and vitamin D synthesis | Homo sapiens |
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Release 2023.1 (January 2023)
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