Literature summary for 1.3.1.21 extracted from

Tadjuidje, E.; Hollemann, T.
Cholesterol homeostasis in development: The role of Xenopus 7-dehydrocholesterol reductase (Xdhcr7) in neural development (2006), Dev. Dyn., 235, 2095-2110.

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Protein Variants

Protein Variants	Comment	Organism
additional information	ectopic and increased cholesterol formation achieved by overexpression of mural Dhcr7 in Xenopus laevis leads to an expansion of the embryonic brain, at least in part at the expense of eye formation	Mus musculus
additional information	knock down of enzyme synthesis by an antisense morpholino oligonucleotide. Inhibition of enzyme synthesis results in disturbance of the expression of eyefield marker genes in the early neurula stage embryos, and alters brain development, as the expression of Xgsh1, which demarcates the intermediate neurons, and that of Xnkx2.2, a ventral forebrain marker, are significantly reduced. Overexpression of large isoform Xdhcr7-L results in an impairment of eye development	Xenopus laevis

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Xenopus laevis	-	large isoform Xdhcr7-L	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
notochord	during early embryonic development, the expression of Xdhcr7 is first of all spatially restricted to the Spemanns organizer and later to the notochord. In both tissues, Xdhcr7 is coexpressed with Sonic hedgehog, Shh	Xenopus laevis	-
Spemanns organizer	during early embryonic development, the expression of Xdhcr7 is first of all spatially restricted to the Spemanns organizer and later to the notochord. In both tissues, Xdhcr7 is coexpressed with Sonic hedgehog, Shh	Xenopus laevis	-

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Release 2023.1 (January 2023)