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Literature summary for 1.3.1.20 extracted from
- Increased expression of dihydrodiol dehydrogenase induces resistance to cisplatin in human ovarian carcinoma cells (2002), J. Biol. Chem., 277, 15035-15043.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | constitutive overexpression of enzyme in 2008 cells leads to induction of cisplatin resistance. In cisplatin-resistant cell-line 2008/C13*, differential expression of enzyme and four more genes is found | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| carboplatin | 50% inhibition at 0.036 mM, 2008 cells, at 0.578 mM, 2008/C13* cells, at 0.097 mM, cells constitutively overexpressing enzyme | Homo sapiens |  |
| cisplatin | 50% inhibition at 0.002 mM, 2008 cells, at 0.019 mM, 2008/C13* cells, at 0.016 mM, cells constitutively overexpressing enzyme | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| carcinoma cell | cisplatin-sensitive ovarian carcinoma cell line 2008 and its cisplatin-resistant variant 2008/C13* | Homo sapiens | - |
| ovary | cisplatin-sensitive ovarian carcinoma cell line 2008 and its cisplatin-resistant variant 2008/C13* | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 500 | - |
substrate 1-indanol, 2008 cells | Homo sapiens |
| 2000 | - |
substrate 1-indanol, 2008 cells constitutively overexpressing enzyme | Homo sapiens |
| 6000 | - |
substrate 1-indanol, 2008/C13* cells | Homo sapiens |
| 7000 | - |
substrate 1-acenaphthol, 2008 cells | Homo sapiens |
| 26000 | - |
substrate 1-acenaphthol, 2008 cells constitutively overexpressing enzyme | Homo sapiens |
| 33000 | - |
substrate 1-acenaphthol, 2008/C13* cells | Homo sapiens |
| 35000 | - |
substrate camphorquinone, 2008 cells | Homo sapiens |
| 65000 | - |
substrate camphorquinone, 2008/C13* cells | Homo sapiens |
| 71000 | - |
substrate camphorquinone, 2008 cells constitutively overexpressing enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-acenaphthol + NADP+ | - |
Homo sapiens | acenaphthylen-1-ol + NADPH | - |
? | |
| 1-indanol + NADP+ | - |
Homo sapiens | 3H-inden-1-ol + NADPH | - |
? | |
| camphorquinone + NADPH | - |
Homo sapiens | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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