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Literature summary for 1.3.1.20 extracted from

  • Higaki, Y.; Kamiya, T.; Usami, N.; Shintani, S.; Shiraishi, H.; Ishikura, S.; Yamamoto, I.; Hara, A.
    Molecular characterization of two monkey dihydrodiol dehydrogenases (2002), Drug Metab. Pharmacokinet., 17, 348-356.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
trans-benzene dihydrodiol pH 7.4, 25°C Macaca fuscata fuscata
0.029
-
(S)-tetralol pH 7.4, 25°C Macaca fascicularis
0.056
-
(R)-tetralol pH 7.4, 25°C Macaca fascicularis
0.073
-
4-chromanol pH 7.4, 25°C Macaca fascicularis
0.076
-
(S)-indan-1-ol pH 7.4, 25°C Macaca fascicularis
0.307
-
(S)-tetralol pH 7.4, 25°C Macaca fuscata fuscata
0.34
-
4-chromanol pH 7.4, 25°C Macaca fuscata fuscata
0.382
-
(R)-tetralol pH 7.4, 25°C Macaca fuscata fuscata
0.42
-
(S)-indan-1-ol pH 7.4, 25°C Macaca fuscata fuscata
0.72
-
trans-benzene dihydrodiol pH 7.4, 25°C Macaca fascicularis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
x * 36000, SDS-PAGE Macaca fascicularis
36000
-
x * 36000, SDS-PAGE Macaca fuscata fuscata

Organism

Organism UniProt Comment Textmining
Macaca fascicularis Q95JH5 isoform DD4
-
Macaca fascicularis Q95JH7 isoform DD1, recombinant enzyme
-
Macaca fuscata fuscata Q95JH4 isoform DD4, recombinant enzyme
-
Macaca fuscata fuscata Q95JH6 isoform DD1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Macaca fascicularis
-
liver
-
Macaca fuscata fuscata
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.9
-
pH 7.4, 25°C Macaca fascicularis
3.9
-
pH 7.4, 25°C Macaca fuscata fuscata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-tetralol + NADP+
-
Macaca fascicularis ?
-
?
(R)-tetralol + NADP+ dehydrogenase activity Macaca fascicularis ? + NADPH
-
r
(R)-tetralol + NADP+ dehydrogenase activity Macaca fuscata fuscata ? + NADPH
-
r
(S)-(+)-1,2,3,4-tetrahydronaphth-1-ol + NADP+
-
Macaca fuscata fuscata ? + NADPH
-
?
(S)-(+)-1,2,3,4-tetrahydronaphth-1-ol + NADP+ dehydrogenase activity Macaca fuscata fuscata ? + NADPH
-
r
(S)-indan-1-ol + NADP+
-
Macaca fascicularis ?
-
?
(S)-indan-1-ol + NADP+ dehydrogenase activity Macaca fascicularis ? + NADPH
-
r
(S)-indan-1-ol + NADP+ dehydrogenase activity Macaca fuscata fuscata ? + NADPH
-
r
(S)-tetralol + NADP+
-
Macaca fascicularis ?
-
?
(S)-tetralol + NADP+ dehydrogenase activity Macaca fascicularis ? + NADPH
-
r
(S)-tetralol + NADP+ dehydrogenase activity Macaca fuscata fuscata ? + NADPH
-
r
4-chromanol + NADP+ dehydrogenase activity Macaca fascicularis ? + NADPH
-
r
4-chromanol + NADP+ dehydrogenase activity Macaca fuscata fuscata ? + NADPH
-
r
4-chromanol + NADP+
-
Macaca fascicularis ?
-
r
additional information no substrate: befunolol, prostaglandin D2, progesterone Macaca fuscata fuscata ?
-
?
S-(+)-1,2,3,4-tetrahydronaphth-1-ol + NADP+
-
Macaca fascicularis ? + NADPH
-
?
S-(+)-1,2,3,4-tetrahydronaphth-1-ol + NADP+ dehydrogenase activity Macaca fascicularis ? + NADPH
-
r
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Macaca fascicularis catechol + NAD(P)H
-
?
trans-benzene dihydrodiol + NADP+ dehydrogenase activity Macaca fascicularis ? + NADPH
-
r
trans-benzene dihydrodiol + NADP+ dehydrogenase activity Macaca fuscata fuscata ? + NADPH
-
r

Subunits

Subunits Comment Organism
? x * 36000, SDS-PAGE Macaca fascicularis
? x * 36000, SDS-PAGE Macaca fuscata fuscata

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Macaca fascicularis
25
-
assay at Macaca fuscata fuscata

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
24.6
-
trans-benzene dihydrodiol pH 7.4, 25°C Macaca fascicularis
84
-
(R)-tetralol pH 7.4, 25°C Macaca fascicularis
90
-
trans-benzene dihydrodiol pH 7.4, 25°C Macaca fuscata fuscata
150
-
4-chromanol pH 7.4, 25°C Macaca fuscata fuscata
1200
-
(S)-indan-1-ol pH 7.4, 25°C Macaca fuscata fuscata
1320
-
(S)-tetralol pH 7.4, 25°C Macaca fascicularis
2040
-
(S)-indan-1-ol pH 7.4, 25°C Macaca fascicularis
2160
-
(S)-tetralol pH 7.4, 25°C Macaca fuscata fuscata
2520
-
(R)-tetralol pH 7.4, 25°C Macaca fuscata fuscata
2880
-
4-chromanol pH 7.4, 25°C Macaca fascicularis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Macaca fascicularis
7.4
-
assay at Macaca fuscata fuscata

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Macaca fuscata fuscata