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Literature summary for 1.3.1.20 extracted from

  • Burczynski, M.E.; Harvey, R.G.; Penning, T.M.
    Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione (1998), Biochemistry, 37, 6781-6790.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DD1, DD2, DD4, type 2 3alpha-hydroxysteroid/dihydrodiol dehydrogenase, expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0035
-
androsterone DD4, DD2 Homo sapiens
0.017
-
trans-benzene dihydrodiol DD4 Homo sapiens
0.022
-
1-Acenaphthenol DD1, DD2 Homo sapiens
0.048
-
1-Indanol DD1 Homo sapiens
0.07
-
1-Acenaphthenol 3alpha-hydroxysteroid/dihydrodiol dehydrogenase Homo sapiens
0.14
-
1-Acenaphthenol DD4 Homo sapiens
0.15
-
trans-benzene dihydrodiol DD1 Homo sapiens
0.17
-
1-Indanol DD4 Homo sapiens
0.32
-
trans-benzene dihydrodiol 3alpha-hydroxysteroid/dihydrodiol dehydrogenase Homo sapiens
0.94
-
1-Indanol DD2 Homo sapiens
1.4
-
1-Indanol 3alpha-hydroxysteroid/dihydrodiol dehydrogenase Homo sapiens
1.8
-
trans-benzene dihydrodiol DD2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P42330 DD1, DD2, DD4, type 2 3alpha-hydroxysteroid/dihydrodiol dehydrogenase
-

Purification (Commentary)

Purification (Comment) Organism
DD1, DD2, DD4 and 3alpha-hydroxysteroid dehydrogenase/dehydrodiol dehydrogenase, all recombinant from Escherichia coli Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ isoforms belong to aldo-keto reductase superfamily Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver cDNAs isolated from HepG2 hepatoma cell line Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.21
-
DD4, substrate androsterone Homo sapiens
2.1
-
recombinant DD1, substrate 1-acenaphthenol Homo sapiens
2.5
-
recombinant DD2, substrate 1-acenaphthenol Homo sapiens
2.8
-
recombinant 3alpha-hydroxysteroid/dihydrodiol dehydrogenase Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-indan-1-ol + NADP+
-
Homo sapiens ?
-
?
1-acenaphthenol + NAD(P)+ recombinant: DD1, DD2, and 3alpha-hydroysteroid dehydrogenase/dihydrodiol dehydrogenase Homo sapiens ?
-
?
1-indanol + NADP+
-
Homo sapiens 3H-inden-1-ol + NADPH
-
?
androsterone + NADPH recombinant DD4 Homo sapiens ?
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Homo sapiens catechol + NAD(P)H
-
?
trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene + NADP+ DD1, DD2, DD4, 3alpha-hydroxysteroid/dihydrodiol dehydrogenase Homo sapiens benzo[a]-pyrene-7,8-dione + NADPH product is potent carcinogen ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00667
-
androsterone DD2 Homo sapiens
0.015
-
trans-benzene dihydrodiol 3alpha-hydroxysteroid/dihydrodiol dehydrogenase Homo sapiens
0.0183
-
trans-benzene dihydrodiol DD2 Homo sapiens
0.0183
-
androsterone DD4 Homo sapiens
0.0333
-
trans-benzene dihydrodiol DD4 Homo sapiens
0.0483
-
trans-benzene dihydrodiol DD1 Homo sapiens
0.0867
-
(S)-indan-1-ol 3alpha-hydroxysteroid/dihydrodiol dehydrogenase Homo sapiens
0.125
-
1-Acenaphthenol DD4 Homo sapiens
0.158
-
(S)-indan-1-ol DD4 Homo sapiens
0.163
-
(S)-indan-1-ol DD2 Homo sapiens
0.208
-
(S)-indan-1-ol DD1 Homo sapiens
0.417
-
1-Acenaphthenol 3alpha-hydroxysteroid/dihydrodiol dehydrogenase Homo sapiens
0.49
-
1-Acenaphthenol DD1 Homo sapiens
0.585
-
1-Acenaphthenol DD2 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens