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Literature summary for 1.3.1.20 extracted from

  • Nanjo, H.; Nishinaka, T.; Nagai, M.; Terada, T.; Mizoguchi, T.; Nishihara, T.
    Unique dihydrodiol specific dehydrogenase of bovine liver: Inhibition studies and comparison with aldo/keto reductase (1993), Adv. Exp. Med. Biol., 328, 371-377.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid) inhibits DD1 and DD3, inhibition can be overcome by androsterone for DD1 and by benzenedihydrodiol for DD3, not vice versa Bos taurus
5alpha-androstan-3,17-dione DD3 Bos taurus
5beta-androstan-3,17-dione DD3 Bos taurus
5beta-Androstan-3alpha-ol-17-one DD3 Bos taurus
androsterone DD3 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0029
-
5beta-androstan-3,17-dione DD1 Bos taurus
0.0031
-
5alpha-androstan-3,17-dione DD1 Bos taurus
0.0048
-
androsterone DD1 Bos taurus
0.0074
-
5beta-Androstan-3alpha-ol-17-one DD1 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
immunologically cross-reactive isoforms DD1 and DD3
-

Purification (Commentary)

Purification (Comment) Organism
DD1 and DD3 Bos taurus

Reaction

Reaction Comment Organism Reaction ID
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ isoform DD1 is identical with 3alpha-hydroxysteroid dehydrogenase EC 1.1.1.50, while isoform DD3 is a unique benzene dihydrodiol-specific enzyme Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha-hydroxy steroid + NADP+ not, DD3 Bos taurus 3-keto steroid + NADPH
-
?
5alpha-androstan-3,17-dione + NADPH isoform DD1, identical with 3alpha-hydroxysteroid dehydrogenase EC 1.1.1.50 Bos taurus 5alpha-androstan-3alpha-ol-17-one + NADP+
-
?
5beta-androstan-3,17-dione + NADPH
-
Bos taurus 5beta-androstan-3alpha-ol-17-one + NADP+
-
?
androsterone + NADPH DD1, identical with 3alpha-hydroxysteroid dehydrogenase EC 1.1.1.50 Bos taurus ?
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ DD3: specific for, no activity towards other alcohols, aldehydes, ketones and quinones Bos taurus catechol + NAD(P)H
-
?
trans-naphthalene dihydrodiol + NAD(P)+
-
Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
DD
-
Bos taurus
dihydrodiol dehydrogenase
-
Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.006
-
androsterone DD3 Bos taurus
0.011
-
5alpha-androstan-3,17-dione DD3 Bos taurus
0.031
-
5beta-Androstan-3alpha-ol-17-one DD3 Bos taurus
0.041
-
5beta-androstan-3,17-dione DD3 Bos taurus