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Literature summary for 1.3.1.2 extracted from

  • Goudgaon, N.M.; Naguib, F.N.M.; el Kouni, M.H.; Schinazi, R.F.
    Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase (1993), J. Med. Chem., 36, 4250-4254.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-(phenylselenenyl)uracil
-
Mus musculus
5-(phenylthio)uracil
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uracil + NADPH
-
Mus musculus 5,6-dihydrouracil + NADP+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0048
-
5-(phenylselenenyl)uracil
-
Mus musculus
0.0054
-
5-(phenylthio)uracil
-
Mus musculus