General Stability | Organism |
---|---|
dithiothreitol stabilizes against inactivation via 5-alkylyluracils | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-Iodouracil | dithiothreitol and thymine protect against inactivation | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + NADPH | Bos taurus | rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines | dihydrothymine + NADP+ | - |
? | |
uracil + NADPH | Bos taurus | - |
5,6-dihydrouracil + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.38 | - |
purified enzyme | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + NADPH + H+ | - |
Bos taurus | 5-fluoro-5,6-dihydrouracil + NADP+ | - |
? | |
5-iodouracil + NADPH | - |
Bos taurus | 5-iodo-5,6-dihydrouracil + NADP+ | alkylating and therefore in vivo inactivating product | ? | |
thymine + NADPH | - |
Bos taurus | dihydrothymine + NADP+ | - |
? | |
thymine + NADPH | rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines | Bos taurus | dihydrothymine + NADP+ | - |
? | |
uracil + NADPH | - |
Bos taurus | 5,6-dihydrouracil + NADP+ | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Bos taurus | |
NADPH | - |
Bos taurus |