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Literature summary for 1.3.1.2 extracted from

  • Hallock, R.O.; Yamada, E.W.
    Pyrimidine reducing enzymes of rat liver (1976), Can. J. Biochem., 54, 178-184.
    View publication on PubMed
Search for more literature for 1.3.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,6-dihydrouracil + NADP+ Rattus norvegicus
-
 uracil + NADPH
-
 ir

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,6-dihydrouracil + NADP+
-
 Rattus norvegicus uracil + NADPH
-
 ir
5,6-dihydrouracil + NADP+ reversibility of the reaction only in vitro Rattus norvegicus uracil + NADPH
-
 r
dihydrothymine + NADP+
-
 Rattus norvegicus thymine + NADPH
-
 r
thymine + NADPH
-
 Rattus norvegicus dihydrothymine + NADP+
-
 r
uracil + NADPH reversibility of the reaction only in vitro Rattus norvegicus 5,6-dihydrouracil + NADP+
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+ less activity than with NADP+, high concentration necessary Rattus norvegicus
NADH less activity than with NADPH, high concentration necessary Rattus norvegicus
NADP+
-
 Rattus norvegicus
NADPH
-
 Rattus norvegicus