Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.124 extracted from

  • Maekelae, A.M.; Hohtola, E.; Miinalainen, I.J.; Autio, J.A.; Schmitz, W.; Niemi, K.J.; Hiltunen, J.K.; Autio, K.J.
    Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and impairment of thermogenesis in mouse brown adipose tissue (2019), Sci. Rep., 9, 12038 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.124

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q9CQ62
-
-
Mus musculus Q9CQ62 isoform Decr1
-

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
2,4-dienoyl-CoA reductase
-
 Mus musculus
DECR
-
 Mus musculus
DECR1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction cold intolerance of Decr-/- mice is due to failure in maintaining appropriate heat production at least partly due to failure of brown adipose tissue (BAT) thermogenesis Mus musculus
metabolism key enzyme required for beta-oxidation of polyunsaturated fatty acids Mus musculus
physiological function cold intolerance of Decr?/? mice is due to failure in maintaining appropriate heat production at least partly due to failure of brown adipose tissue thermogenesis. Activation of lipolysis is attenuated despite of functional norepinephrine-signaling and inappropriate expression of genes contributing to thermogenesis in interscapular brown adipose rissue when the Decr?/? mice are exposed to cold Mus musculus