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Literature summary for 1.3.1.124 extracted from

  • Roe, C.R.; Millington, D.S.; Norwood, D.L.; Sprecher, H.; Mohammed, B.S.; Nada, M.; Schulz, H.; McVie, R.
    2,4-Dienolyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation (1990), J. Clin. Invest., 85, 1703-1707.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.124

Inhibitors

Inhibitors Comment Organism Structure
lysine slight inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-trans,4-cis-decadienoylcarnitine + ? Homo sapiens abnormal unsaturated fatty acid oxidation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 female, in the neonatal period
-

Source Tissue

Source Tissue Comment Organism Textmining
liver soluble tissue extract for the enzyme assays Homo sapiens
-
muscle soluble tissue extract for the enzyme assays Homo sapiens
-
urine source of the natural substrate 2-trans,4cis-decadienoylcarnitine Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.003
-
 2-trans,4-trans-decadienoyl-CoA, NADPH, muscle Homo sapiens
0.0046
-
 2-trans,4-cis-decadienoyl-CoA, NADPH, muscle Homo sapiens
0.0084
-
 2-trans,4-trans-decadienoyl-CoA, NADPH, liver Homo sapiens
0.013
-
 2-trans,4-cis-decadienoyl-CoA, NADPH, liver Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-trans,4-cis-decadienoyl-CoA + NADPH
-
 Homo sapiens 3-trans-decenoyl-CoA + NADP+
-
 ?
2-trans,4-cis-decadienoylcarnitine + ? abnormal unsaturated fatty acid oxidation Homo sapiens ?
-
 ?
2-trans,4-trans-decadienoyl-CoA + NADPH
-
 Homo sapiens 3-decenoyl-CoA + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
2,4-dienoyl-CoA reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens