Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyphenylacetate | - |
Escherichia coli | |
5,6-dihydro-5,6-dihydroxychorismate | - |
Escherichia coli | |
adamantane-1,3-diacetate | - |
Escherichia coli | |
adamantane-1-acetate | - |
Escherichia coli | |
adamantane-1-carboxylate | - |
Escherichia coli | |
adamantane-1-phosphonate | - |
Escherichia coli | |
chorismate-5,6-epoxide | - |
Escherichia coli | |
trans-2,3-pleiadanedicarboxylic acid | i.e. diacid, 50% inhibition at 0.25 mM, inhibits competitively the prephenate dehydrogenase activity, but not the chorismate mutase activity of the enzyme | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prephenate + NAD+ | Escherichia coli | second step in the biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + CO2 + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+ | the T-protein is a bifunctional enzyme showing chorismate mutase, EC 5.4.99.5, and prephenate dehydrogenase activities at two separate active sites | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prephenate + NAD+ | - |
Escherichia coli | 4-hydroxyphenylpyruvate + CO2 + NADH | - |
? | |
prephenate + NAD+ | second step in the biosynthesis of L-tyrosine | Escherichia coli | 4-hydroxyphenylpyruvate + CO2 + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
T-protein | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.11 | - |
5,6-dihydro-5,6-dihydroxychorismate | pH 7.8, 37°C | Escherichia coli | |
0.13 | - |
adamantane-1-acetate | pH 7.8, 37°C | Escherichia coli | |
0.13 | - |
chorismate-5,6-epoxide | pH 7.8, 37°C | Escherichia coli | |
0.14 | - |
adamantane-1-phosphonate | pH 7.8, 37°C | Escherichia coli | |
0.15 | - |
adamantane-1,3-diacetate | pH 7.8, 37°C | Escherichia coli | |
0.17 | - |
2-hydroxyphenylacetate | pH 7.8, 37°C | Escherichia coli | |
0.21 | - |
trans-2,3-pleiadanedicarboxylic acid | pH 7.8, 37°C | Escherichia coli | |
0.31 | - |
adamantane-1-carboxylate | pH 7.8, 37°C | Escherichia coli | |
0.59 | - |
CKTENMQSC | pH 7.8, 37°C | Escherichia coli |