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Literature summary for 1.3.1.12 extracted from
- The enzymology of prephenate dehydrogenase in Bacillus subtilis (1970), J. Biol. Chem., 245, 3763-3770.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxyphenylpyruvate | - |
Bacillus subtilis |  |
| D-tyrosine | - |
Bacillus subtilis | |
| L-phenylalanine | - |
Bacillus subtilis | |
| L-tryptophan | - |
Bacillus subtilis | |
| L-tyrosine | - |
Bacillus subtilis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
NAD+ | - |
Bacillus subtilis | |
| 2 | - |
prephenate | - |
Bacillus subtilis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| KCl | required for optimal activity | Bacillus subtilis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate + NAD+ | Bacillus subtilis | biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bacillus subtilis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate + NAD+ | - |
Bacillus subtilis | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| prephenate + NAD+ | biosynthesis of L-tyrosine | Bacillus subtilis | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 32 | - |
- |
Bacillus subtilis |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
decrease of activity above | Bacillus subtilis |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
L-tyrosine, protection against thermal inactivation | Bacillus subtilis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.4 | - |
- |
Bacillus subtilis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | NADP+ cannot substitute for NAD+ | Bacillus subtilis | |
| NAD+ | - |
Bacillus subtilis | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
L-tyrosine | - |
Bacillus subtilis | |
| 0.3 | - |
L-phenylalanine | - |
Bacillus subtilis | |
| 0.4 | - |
4-hydroxyphenylpyruvate | - |
Bacillus subtilis | |
| 0.7 | - |
L-tryptophan | - |
Bacillus subtilis | |
| 1.3 | - |
D-tyrosine | - |
Bacillus subtilis | |
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Release 2023.1 (January 2023)
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