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Literature summary for 1.3.1.12 extracted from
- Kinetic studies on the reactions catalyzed by chorismate mutase-prephenate dehydrogenase from Aerobacter aerogenes (1978), Biochemistry, 17, 1573-1580.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bovine serum albumin | - |
Klebsiella aerogenes |
General Stability
| General Stability | Organism |
|---|---|
| glycerol stabilizes | Klebsiella aerogenes |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxyphenylpyruvate | - |
Klebsiella aerogenes |  |
| AMP | - |
Klebsiella aerogenes | |
| additional information | substrate analogues | Klebsiella aerogenes | |
| NADH | - |
Klebsiella aerogenes | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate + NAD+ | Klebsiella aerogenes | biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella aerogenes | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| chorismate mutase-prephenate dehydrogenase bifunctional enzyme | Klebsiella aerogenes |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 33 | - |
chorismate mutase-prephenate dehydrogenase bifunctional enzyme | Klebsiella aerogenes |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -15°C, 0.02% sodium azide, N2-atmosphere, more than 0.1 mg/ml protein | Klebsiella aerogenes |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate + NAD+ | mechanism, kinetic studies | Klebsiella aerogenes | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
ir | |
| prephenate + NAD+ | biosynthesis of L-tyrosine | Klebsiella aerogenes | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| chorismate mutase-prephenate dehydrogenase bifunctional enzyme | complex with EC 5.4.99.5 | Klebsiella aerogenes |
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