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Literature summary for 1.3.1.12 extracted from

  • Ahmad, S.; Jensen, R.A.
    The prephenate dehydrogenase component of the bifunctional T-protein in enteric bacteria can utilize L-arogenate (1987), FEBS Lett., 216, 133-139.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-tyrosine
-
Escherichia coli
L-tyrosine
-
Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prephenate + NAD+ Escherichia coli biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
?
prephenate + NAD+ Klebsiella pneumoniae biosynthesis of L-tyrosine 4-hydroxyphenylpyruvate + NADH + CO2
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
K12
-
Escherichia coli
-
strains B and W
-
Klebsiella pneumoniae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
chorismate mutase-prephenate dehydrogenase bifunctional enzyme Escherichia coli
chorismate mutase-prephenate dehydrogenase bifunctional enzyme Klebsiella pneumoniae
partial Escherichia coli
partial Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arogenate + NAD+
-
Escherichia coli L-tyrosine + NADH + CO2
-
?
L-arogenate + NAD+
-
Klebsiella pneumoniae L-tyrosine + NADH + CO2
-
?
prephenate + NAD+
-
Escherichia coli 4-hydroxyphenylpyruvate + NADH + CO2
-
?
prephenate + NAD+
-
Klebsiella pneumoniae 4-hydroxyphenylpyruvate + NADH + CO2
-
?
prephenate + NAD+ biosynthesis of L-tyrosine Escherichia coli 4-hydroxyphenylpyruvate + NADH + CO2
-
?
prephenate + NAD+ biosynthesis of L-tyrosine Klebsiella pneumoniae 4-hydroxyphenylpyruvate + NADH + CO2
-
?

Synonyms

Synonyms Comment Organism
bifunctional T-protein
-
Escherichia coli
bifunctional T-protein
-
Klebsiella pneumoniae
chorismate mutase-prephenate dehydrogenase bifunctional enzyme complex with EC 5.4.99.5 Escherichia coli
chorismate mutase-T:prephenate dehydrogenase bifunctional enzyme
-
Escherichia coli
chorismate mutase-T:prephenate dehydrogenase bifunctional enzyme
-
Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
additional information NADP+ cannot substitute for NAD+ Escherichia coli
additional information NADP+ cannot substitute for NAD+ Klebsiella pneumoniae
NAD+
-
Escherichia coli
NAD+
-
Klebsiella pneumoniae