BRENDA - Enzyme Database
show all sequences of 1.3.1.118

Kinetic and equilibrium mechanisms of substrate binding to Mycobacterium tuberculosis enoyl reductase Implications to function-based antitubercular agent design

Vasconcelos, I.; Basso, L.; Santos, D.; J. Braz. Chem. Soc. 21, 1503-1508 (2010)
No PubMed abstract available

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mycobacterium tuberculosis
-
-
-
Purification (Commentary)
Commentary
Organism
-
Mycobacterium tuberculosis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
trans-2-dodecenoyl-CoA + NADH + H+
pre-steady state kinetics and equilibrium data of 2-trans-dodecenoyl-CoA substrate binding to InhA. The results indicate both positive homotropic cooperativity upon substrate binding to InhA, and a bimolecular association process followed by a slow isomerization of the enzyme-substrate binary complex
748277
Mycobacterium tuberculosis
dodecanoyl-CoA + NAD+
-
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Mycobacterium tuberculosis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
trans-2-dodecenoyl-CoA + NADH + H+
pre-steady state kinetics and equilibrium data of 2-trans-dodecenoyl-CoA substrate binding to InhA. The results indicate both positive homotropic cooperativity upon substrate binding to InhA, and a bimolecular association process followed by a slow isomerization of the enzyme-substrate binary complex
748277
Mycobacterium tuberculosis
dodecanoyl-CoA + NAD+
-
-
-
?
Other publictions for EC 1.3.1.118
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747250
Joshi
Pharmacophore mapping, molecu ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Bioorg. Chem.
81
440-453
2018
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1
1
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5
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1
1
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747697
Chollet
An overview on crystal struct ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Eur. J. Med. Chem.
146
318-343
2018
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1
7
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2
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748518
Xia
Discovery of a cofactor-indep ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Life Sci. Alliance
1
e201800025
2018
-
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1
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8
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6
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748042
Spagnuolo
Evaluating the contribution o ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
J. Am. Chem. Soc.
139
3417-3429
2017
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18
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747582
Guardia
N-Benzyl-4-((heteroaryl)methy ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
ChemMedChem
11
687-701
2016
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1
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26
-
-
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19
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747703
Rotta
Piperazine derivatives Synthe ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Eur. J. Med. Chem.
90
436-447
2015
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10
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1
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747700
Pedgaonkar
Development of 2-(4-oxoquinaz ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Eur. J. Med. Chem.
86
613-627
2014
-
1
1
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28
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28
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747629
Pan
Targeting InhA, the FASII eno ...
Mycobacterium tuberculosis
Curr. Top. Med. Chem.
12
672-693
2012
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748433
Da Costa
Conformational changes in 2-t ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
J. Mol. Model.
18
1779-1790
2012
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748167
Luckner
A slow, tight binding inhibit ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
J. Biol. Chem.
285
14330-14337
2010
-
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1
1
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1
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19
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748277
Vasconcelos
-
Kinetic and equilibrium mecha ...
Mycobacterium tuberculosis
J. Braz. Chem. Soc.
21
1503-1508
2010
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748516
Gurvitz
Triclosan inhibition of mycob ...
Mycobacterium tuberculosis
Lett. Appl. Microbiol.
50
399-405
2010
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1
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2
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748622
Lu
Recent progress in the identi ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Mini Rev. Med. Chem.
10
182-193
2010
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18
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748680
Molle
Phosphorylation of InhA inhib ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Mol. Microbiol.
78
1591-1605
2010
-
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1
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3
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4
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19
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1
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1
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4
747498
Subba Rao
Structure-based design of a n ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Chem. Biol. Drug Des.
72
444-449
2008
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2
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1
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747251
He
Inhibition of the Mycobacteri ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Bioorg. Med. Chem.
15
6649-6658
2007
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1
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12
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19
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12
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1
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748020
Argyrou
New insight into the mechanis ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
J. Am. Chem. Soc.
129
9582-9583
2007
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749238
Kruh
Probing mechanisms of resista ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Protein Sci.
16
1617-1627
2007
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1
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3
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1
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19
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747286
Schroeder
Molecular dynamics simulation ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Biophys. J.
89
876-884
2005
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2
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746762
Nguyen
Mn(III) pyrophosphate as an e ...
Mycobacterium tuberculosis
Antimicrob. Agents Chemother.
46
2137-2144
2002
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1
1
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747579
Nguyen
-
The nonenzymatic activation o ...
Mycobacterium tuberculosis
Chemistry
4
35-40
2001
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748073
Vilcheze
Inactivation of the inhA-enco ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155
J. Bacteriol.
182
4059-4067
2000
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1
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748605
Marrakchi
InhA, a target of the antitub ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis mc(2)155
Microbiology
146
289-296
2000
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3
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748146
Rozwarski
Crystal structure of the Myco ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
J. Biol. Chem.
274
15582-15598
1999
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1
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20
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1
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747053
Quemard
Enzymatic characterization of ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Biochemistry
34
8235-8241
1995
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1
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12
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20
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10
1
1
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1
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