Literature summary for 1.3.1.118 extracted from

Vilcheze, C.; Morbidoni, H.; Weisbrod, T.; Iwamoto, H.; Kuo, M.; Sacchettini, J.; Jacobs Jr., W.
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis (2000), J. Bacteriol., 182, 4059-4067 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
isoniazid	-	Mycolicibacterium smegmatis

Organism

Organism	UniProt	Comment	Textmining
Mycolicibacterium smegmatis	P42829	-	-
Mycolicibacterium smegmatis mc(2)155	P42829	-	-

Synonyms

Synonyms	Comment	Organism
InhA	-	Mycolicibacterium smegmatis

General Information

General Information	Comment	Organism
malfunction	thermal inactivation of InhA at 42°C in Mycobacterium smegmatis results in the inhibition of mycolic acid biosynthesis, a decrease in hexadecanoic acid (C16:0) and a concomitant increase of tetracosanoic acid (C24:0) in a manner equivalent to that seen in isoniazid-treated cells. The InhA-inactivated cells, like isoniazid-treated cells, undergo a drastic morphological change, leading to cell lysis. InhA inactivation, alone, is sufficient to induce the accumulation of saturated fatty acids, cell wall alterations, and cell lysis	Mycolicibacterium smegmatis

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Release 2023.1 (January 2023)