BRENDA - Enzyme Database show
show all sequences of 1.3.1.106

Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12)

Moore, S.; Lawrence, A.; Biedendieck, R.; Deery, E.; Frank, S.; Howard, M.; Rigby, S.; Warren, M.; Proc. Natl. Acad. Sci. USA 110, 14906-14911 (2013)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
homologously overproduced enzyme
Bacillus megaterium
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cobalt-precorrin-6A + NADH + H+
Bacillus megaterium
the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis
cobalt-precorrin-6B + NAD+
-
-
?
cobalt-precorrin-6A + NADH + H+
Bacillus megaterium DSM 509
the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis
cobalt-precorrin-6B + NAD+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bacillus megaterium
-
-
-
Bacillus megaterium DSM 509
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cobalt-precorrin-6A + NADH + H+
no activity with NADPH
726391
Bacillus megaterium
cobalt-precorrin-6B + NAD+
-
-
-
?
cobalt-precorrin-6A + NADH + H+
the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis
726391
Bacillus megaterium
cobalt-precorrin-6B + NAD+
-
-
-
?
cobalt-precorrin-6A + NADH + H+
no activity with NADPH
726391
Bacillus megaterium DSM 509
cobalt-precorrin-6B + NAD+
-
-
-
?
cobalt-precorrin-6A + NADH + H+
the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis
726391
Bacillus megaterium DSM 509
cobalt-precorrin-6B + NAD+
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
no activity with NADPH
Bacillus megaterium
Cloned(Commentary) (protein specific)
Commentary
Organism
homologously overproduced enzyme
Bacillus megaterium
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
no activity with NADPH
Bacillus megaterium
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cobalt-precorrin-6A + NADH + H+
Bacillus megaterium
the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis
cobalt-precorrin-6B + NAD+
-
-
?
cobalt-precorrin-6A + NADH + H+
Bacillus megaterium DSM 509
the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis
cobalt-precorrin-6B + NAD+
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cobalt-precorrin-6A + NADH + H+
no activity with NADPH
726391
Bacillus megaterium
cobalt-precorrin-6B + NAD+
-
-
-
?
cobalt-precorrin-6A + NADH + H+
the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis
726391
Bacillus megaterium
cobalt-precorrin-6B + NAD+
-
-
-
?
cobalt-precorrin-6A + NADH + H+
no activity with NADPH
726391
Bacillus megaterium DSM 509
cobalt-precorrin-6B + NAD+
-
-
-
?
cobalt-precorrin-6A + NADH + H+
the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis
726391
Bacillus megaterium DSM 509
cobalt-precorrin-6B + NAD+
-
-
-
?
Other publictions for EC 1.3.1.106
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
726391
Moore
Elucidation of the anaerobic p ...
Bacillus megaterium, Bacillus megaterium DSM 509
Proc. Natl. Acad. Sci. USA
110
14906-14911
2013
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671664
Kim
Role of the precorrin 6-X redu ...
Methanococcus maripaludis, Methanococcus maripaludis JJ
Archaea
1
375-384
2005
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