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Literature summary for 1.3.1.106 extracted from

  • Moore, S.; Lawrence, A.; Biedendieck, R.; Deery, E.; Frank, S.; Howard, M.; Rigby, S.; Warren, M.
    Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12) (2013), Proc. Natl. Acad. Sci. USA, 110, 14906-14911.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
homologously overproduced enzyme Priestia megaterium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cobalt-precorrin-6A + NADH + H+ Priestia megaterium the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis cobalt-precorrin-6B + NAD+
-
?
cobalt-precorrin-6A + NADH + H+ Priestia megaterium DSM 509 the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis cobalt-precorrin-6B + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Priestia megaterium
-
-
-
Priestia megaterium DSM 509
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cobalt-precorrin-6A + NADH + H+ no activity with NADPH Priestia megaterium cobalt-precorrin-6B + NAD+
-
?
cobalt-precorrin-6A + NADH + H+ the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis Priestia megaterium cobalt-precorrin-6B + NAD+
-
?
cobalt-precorrin-6A + NADH + H+ no activity with NADPH Priestia megaterium DSM 509 cobalt-precorrin-6B + NAD+
-
?
cobalt-precorrin-6A + NADH + H+ the enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis Priestia megaterium DSM 509 cobalt-precorrin-6B + NAD+
-
?

Synonyms

Synonyms Comment Organism
CbiJ
-
Priestia megaterium

Cofactor

Cofactor Comment Organism Structure
NADH no activity with NADPH Priestia megaterium