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Literature summary for 1.3.1.104 extracted from

  • Demissie, R.; Kabre, P.; Fung, L.
    Nonactive-site mutations in S. aureus FabI that induce triclosan resistance (2020), ACS Omega, 5, 23175-23183 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.104

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli CodonPlus(DE3)-RIL cells Staphylococcus aureus

Protein Variants

Protein Variants Comment Organism
A230T triclosan-resistant mutant Staphylococcus aureus
A95V active-site mutant Staphylococcus aureus
D66Y active-site mutant Staphylococcus aureus
F204S active-site mutant Staphylococcus aureus
F252I triclosan-resistant mutant Staphylococcus aureus
G113V triclosan-resistant mutant Staphylococcus aureus
G227C triclosan-resistant mutant Staphylococcus aureus
H253P triclosan-resistant mutant Staphylococcus aureus
K164R active-site mutant Staphylococcus aureus
N220I triclosan-resistant mutant Staphylococcus aureus
S166N triclosan-resistant mutant Staphylococcus aureus
V241I triclosan-resistant mutant Staphylococcus aureus
Y123H triclosan-resistant mutant Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
triclosan
-
 Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Subunits

Subunits Comment Organism
homodimer 2 * 34000, SDS-PAGE Staphylococcus aureus

Synonyms

Synonyms Comment Organism
enoyl-ACP reductase
-
 Staphylococcus aureus
FabI
-
 Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Staphylococcus aureus