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Literature summary for 1.3.1.101 extracted from

  • Nishimura, Y.; Eguchi, T.
    Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum (2006), J. Biochem., 139, 1073-1081.
    View publication on PubMed
Search for more literature for 1.3.1.101

Inhibitors

Inhibitors Comment Organism Structure
additional information EDTA has little effect on activity Thermoplasma acidophilum

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane associated protein Thermoplasma acidophilum 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information the enzyme does not require metal ions for activity Thermoplasma acidophilum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 x * 45000, SDS-PAGE Thermoplasma acidophilum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ Thermoplasma acidophilum formation of 2,3-di-O-phytanyl-sn-glyceryl phosphate (archaetidic acid), which is the basic core structure of archaeal membrane lipids 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + 8 NAD(P)+
-
 ?

Organism

Organism UniProt Comment Textmining
Thermoplasma acidophilum Q9HKS9
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Thermoplasma acidophilum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0115
-
 pH 6.5, 50°C, substrate: 2,3-di-O-geranylgeranyl-sn-glycerol 1-phosphate Thermoplasma acidophilum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+
-
 Thermoplasma acidophilum 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + 8 NAD(P)+
-
 ?
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+ formation of 2,3-di-O-phytanyl-sn-glyceryl phosphate (archaetidic acid), which is the basic core structure of archaeal membrane lipids Thermoplasma acidophilum 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + 8 NAD(P)+
-
 ?
2,3-bis-O-phytyl-sn-glycero-phosphoethanolamine + NAD(P)H + H+
-
 Thermoplasma acidophilum ?
-
 ?
2,3-bis-O-phytyl-sn-glyceryl phosphate + NAD(P)H + H+
-
 Thermoplasma acidophilum 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + NAD(P)+
-
 ?
3-O-(2,3-bis-O-phytyl-sn-glycero-phospho)-sn-glycerol + NAD(P)H + H+
-
 Thermoplasma acidophilum ?
-
 ?
additional information neither 2,3-bis-O-geranylgeranylglycerol nor 2,3-bis-O-geranylgeranylglyceryl phosphate dimethyl ester is recognized as a substrate Thermoplasma acidophilum ?
-
 ?

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE Thermoplasma acidophilum

Synonyms

Synonyms Comment Organism
Ta0516m
-
 Thermoplasma acidophilum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
50
-
 aassay at Thermoplasma acidophilum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Thermoplasma acidophilum

Cofactor

Cofactor Comment Organism Structure
FAD required for activity Thermoplasma acidophilum
NAD(P)H required for activity Thermoplasma acidophilum