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Literature summary for 1.23.1.3 extracted from

  • Zhao, Q.; Zeng, Y.; Yin, Y.; Pu, Y.; Jackson, L.A.; Engle, N.L.; Martin, M.Z.; Tschaplinski, T.J.; Ding, S.Y.; Ragauskas, A.J.; Dixon, R.A.
    Pinoresinol reductase 1 impacts lignin distribution during secondary cell wall biosynthesis in Arabidopsis (2015), Phytochemistry, 112, 170-178 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene PrR1, PrR1 is co-expressed with many characterized genes involved in secondary cell wall biosynthesis, gene co-expression networks for Arabidopsis thaliana PrR1 and PrR2, overview. PrR1 is regulated by the secondary cell wall transcription factors SND1 and MYB46 Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information the prr1-1 knock-out mutant SALK_058467 contains a T-DNA insertion within an exonic region of the PrR1 gene. The concentration of the lignan, pinoresinol, is 4.8fold higher in the loss-of-function prr1 mutant than in control plants. Impact of loss of function of PrR1 on the cellular distribution of lignin Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(-)-pinoresinol + NADPH + H+ Arabidopsis thaliana
-
(-)-lariciresinol + NADP+
-
?
additional information Arabidopsis thaliana (-)-pinoresinol is successively converted into (-)-lariciresinol and (+)-secoisolariciresinol by isozyme PrR1, cf. Ec 1.23.1.4 ?
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9FVQ6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information PrR1 is highly expressed in lignified inflorescence stem tissue Arabidopsis thaliana
-
seed coat
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-pinoresinol + NADPH + H+
-
Arabidopsis thaliana (-)-lariciresinol + NADP+
-
?
additional information (-)-pinoresinol is successively converted into (-)-lariciresinol and (+)-secoisolariciresinol by isozyme PrR1, cf. Ec 1.23.1.4 Arabidopsis thaliana ?
-
?

Synonyms

Synonyms Comment Organism
bi-functional pinoresinol/lariciresinol reductase
-
Arabidopsis thaliana
More cf. EC 1.23.1.4 Arabidopsis thaliana
pinoresinol reductase
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Arabidopsis thaliana
pinoresinol reductase 1
-
Arabidopsis thaliana
PLR
-
Arabidopsis thaliana
PrR1
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction the loss-of-function mutant of PrR1 shows, in addition to elevated levels of pinoresinol, significantly decreased lignin content and a slightly altered lignin structure with lower abundance of cinnamyl alcohol end groups. Stimulated Raman scattering (SRS) microscopy analysis indicates that the lignin content of the prr1-1 loss-of-function mutant is similar to that of wild-type plants in xylem cells, which exhibit a normal phenotype, but is reduced in the fiber cells. The concentration of the lignan, pinoresinol, is 4.8fold higher in the loss-of-function prr1 mutant than in control plants. Impact of loss of function of PrR1 on the cellular distribution of lignin. The PrR1 isozyme mutation alters the expression level of diverse genes, overview Arabidopsis thaliana
metabolism pinoresinol is successively converted into lariciresinol and secoisolariciresinol by PrR. Secoisolariciresinol is glycosylated to secoisolariciresinol diglucoside (SDG). PLR has enantiomeric control on the lignan biosynthetic pathway Arabidopsis thaliana
physiological function pinoresinol reductase (PrR) catalyzes the conversion of the lignan pinoresinol to lariciresinol in Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. Association of the lignan biosynthetic enzyme encoded by PrR1 with secondary cell wall biosynthesis in fiber cells. PrR1 is regulated by the secondary cell wall transcription factors SND1 and MYB46. PrR1 plays a role in lignan biosynthesis in aerial tissue Arabidopsis thaliana