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Literature summary for 1.21.99.3 extracted from
- Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity (2017), Endocrinology, 158, 419-430 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Dio3 | - |
Mus musculus |
| type 3 deiodinase | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme-deficient mice of both sexes exhibit decreased adiposity, reduced brown and white adipocyte size, and enhanced fat loss in response to triiodothyronine treatment. They also exhibit increased thyroid hormone action in the hypothalamus, with abnormal expression and triiodothyronine sensitivity of genes integral to the leptin-melanocortin system, including Agrp, Npy, Pomc, and Mc4r. Enzyme-deficient mice also display elevated locomotor activity and increased energy expenditure | Mus musculus |
| physiological function | enzyme-mediated regulation of thyroid hormone action in the central nervous system influences multiple critical determinants of energy balance | Mus musculus |
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Release 2023.1 (January 2023)
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