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Literature summary for 1.21.99.3 extracted from

  • Galton, V.A.; Hernandez, A.; St Germain, D.L.
    The 5-deiodinases are not essential for the fasting-induced decrease in circulating thyroid hormone levels in male mice: possible roles for the type 3 deiodinase and tissue sequestration of hormone (2014), Endocrinology, 155, 3172-3181.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.21.99.3

Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme knockout mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q91ZI8
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-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
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liver
-
 Mus musculus
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additional information type 3 deiodinase activity, although normally expressed at very low levels in adult peripheral tissues, is increased to significant levels in the skin, kidney, and muscle of both fasted wild-type and type 1 and 2 deiodinase KO mice Mus musculus
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muscle
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 Mus musculus
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skin
-
 Mus musculus
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Synonyms

Synonyms Comment Organism
5'-deiodinase
-
 Mus musculus
type 3 deiodinase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme activity is increased in kidney, muscle, and liver up to 4fold during fasting up

General Information

General Information Comment Organism
physiological function type 3 deiodinase plays a role in the fasting-induced alterations in thyroid hormone homeostasis. The enzyme activity is increased in kidney, muscle, and liver up to 4fold during fasting. The observed fasting-induced reductions in the circulating T3 and T4 levels are mediated in part by increased the enzyme activity and by the sequestration of thyroid hormone and their metabolites in tissues, overview Mus musculus