Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iopanoic acid | - |
Danio rerio | |
additional information | the measured zD3 activity is unaffected by 1 mM propylthiouracil | Danio rerio |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | D3Y4D3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,5,3'-triiodo-L-thyronine + AH2 | - |
Danio rerio | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
deiodinase-3 | - |
Danio rerio |
type 3 deiodinase | - |
Danio rerio |
zD3 | - |
Danio rerio |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Danio rerio |
Organism | Comment | Expression |
---|---|---|
Danio rerio | the mRNA expression and activity of the zebrafish deiodinase-3 gene is increased locally 1 and 3 days after partial fin amputation | up |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of deiodinase-3 activity with iopanoic acid alone causes strong inhibition (58%) of blastema formation | Danio rerio |
physiological function | the local inactivation of thyroid hormone by deiodinase-3 is important for cell proliferation | Danio rerio |