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Literature summary for 1.21.99.3 extracted from

  • Ng, L.; Hernandez, A.; He, W.; Ren, T.; Srinivas, M.; Ma, M.; Galton, V.A.; St Germain, D.L.; Forrest, D.
    A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function (2009), Endocrinology, 150, 1952-1960.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.21.99.3

Organism

Organism UniProt Comment Textmining
Mus musculus Q91ZI8 wild-type and type 3 deiodinase knockdown mice
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Source Tissue

Source Tissue Comment Organism Textmining
cochlea
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 Mus musculus
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pup
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5-triiodo-L-thyronine + AH2
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 Mus musculus 3,3'-diiodothyronine + iodide + A + H+
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 ?

Synonyms

Synonyms Comment Organism
Dio3
-
 Mus musculus
type 3 deiodinase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
dithiothreitol 50 mM Mus musculus

Expression

Organism Comment Expression
Mus musculus decrease postnatally, persisted into adulthood at low levels down
Mus musculus high expressio levels in embryos up

General Information

General Information Comment Organism
physiological function protective role in hearing by influence of thyroid hormone, influence on cochlear development and auditory function, thyroid hormone-inactivating enzyme Mus musculus