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Literature summary for 1.21.99.3 extracted from

  • Shintani, N.; Nohira, T.; Hikosaka, A.; Kawahara, A.
    Tissue-specific regulation of type III iodothyronine 5-deiodinase gene expression mediates the effects of prolactin and growth hormone in Xenopus metamorphosis (2002), Dev. Growth Differ., 44, 327-335.
    View publication on PubMed
Search for more literature for 1.21.99.3

Activating Compound

Activating Compound Comment Organism Structure
growth hormone slightly upregulates the 5-deiodinase mRNA expression in the tail, but strongly downregulates it in the liver Xenopus laevis
prolactin upregulates the 5-deiodinase mRNA expression in the tail, but downregulates it in the liver Xenopus laevis

Inhibitors

Inhibitors Comment Organism Structure
3,3',5-triiodo-L-thyronine isozyme type III, inhibition of tail growth Xenopus laevis
growth hormone upregulates the 5-deiodinase mRNA expression in the tail, but downregulates it in the liver Xenopus laevis
iopanoic acid isozyme type III; tail growth inhibition Xenopus laevis
prolactin inhibits the 3,3',5-triiodo-L-thyronine-dependent upregulation of thyroid hormone receptor beta mRNA expression in the tail; inhibits the regression of the tail fin; upregulates the 5-deiodinase mRNA expression in the tail, but downregulates it in the liver Xenopus laevis

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
 isozyme type III
-
Xenopus laevis
-
 adult and tadpole
-
Xenopus laevis Q90Z53 isozyme type II, 5'-deiodinase activity
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isozyme type III Xenopus laevis
-
hepatocyte larval, primary Xenopus laevis
-
intestine no measurable expression of isozyme type III Xenopus laevis
-
kidney no measurable expression of isozyme type III Xenopus laevis
-
larva premetamorphic Xenopus laevis
-
liver isozyme type III Xenopus laevis
-
tail organ culture of tadpole tail tips Xenopus laevis
-
tissue culture of tadpole tail tips Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodo-L-thyronine + AH2 type I isozyme Xenopus laevis 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
3,3',5-triiodo-L-thyronine + AH2 isozyme type III Xenopus laevis 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?