Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.21.99.3 extracted from

  • Santini, F.; Pinchera, A.; Ceccarini, G.; Castagna, M.; Rosellini, V.; Mammoli, C.; Montanelli, L.; Zucchi, V.; Chopra, I.J.; Chiovato, L.
    Evidence for a role of the type III-iodothyronine deiodinase in the regulation of 3,5,3'-triiodothyronine content in the human central nervous system (2001), Eur. J. Endocrinol., 144, 577-583.
    View publication on PubMed
Search for more literature for 1.21.99.3

Inhibitors

Inhibitors Comment Organism Structure
3,3',5'-triiodo-L-thyronine no effect up to 100 nM Homo sapiens
3,3',5,5'-tetraiodo-L-thyronine substrate inhibition of isozyme type III Homo sapiens
3,3',5-triiodo-L-thyronine substrate inhibition of isozyme type III, complete inhibition at 25 nM Homo sapiens
3,5-diiodo-L-thyronine substrate inhibition of isozyme type III Homo sapiens
aurothioglucose isozyme type III, 90% inhibition at 0.001 mM Homo sapiens
iopanoic acid 90% inhibition at 0.002 mM; isozyme type III Homo sapiens
additional information 3,3',5-triiodo-L-thyronine sulfate has no effect on isozyme type III in hippocampus up to 100 nM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000011
-
 3,3',5'-triiodo-L-thyronine pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome isozyme type III Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5-triiodo-L-thyronine + AH2 Homo sapiens enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content 3,3'-diiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
3,3',5-triiodo-L-thyronine + AH2 Homo sapiens enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content 3,3'-diiodo-L-thyronine + iodide + A + H+ i.e. 3,3'-diiodo-L-thyronine ?
L-thyroxine + AH2 Homo sapiens 5-deiodinase activity 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
L-thyroxine + AH2 Homo sapiens 5-deiodinase activity 3,3',5'-triiodo-L-thyronine + iodide + A + H+ enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content ?
L-thyroxine + AH2 Homo sapiens isozyme type III 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
additional information Homo sapiens thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme type III
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isozyme type III Homo sapiens
-
central nervous system isozyme type III Homo sapiens
-
hippocampus isozyme type III Homo sapiens
-
additional information isozyme type III ativity in brain areas, overview Homo sapiens
-
temporal cortex isozyme type III Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5-triiodo-L-thyronine + AH2 isozyme type III Homo sapiens 3,3'-diiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
3,3',5-triiodo-L-thyronine + AH2 enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content Homo sapiens 3,3'-diiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
3,3',5-triiodo-L-thyronine + AH2 enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content Homo sapiens 3,3'-diiodo-L-thyronine + iodide + A + H+ i.e. 3,3'-diiodo-L-thyronine ?
L-thyroxine + AH2 isozyme type III Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
L-thyroxine + AH2 5-deiodinase activity Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
L-thyroxine + AH2 5-deiodinase activity Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+ enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content ?
L-thyroxine + AH2 isozyme type III Homo sapiens 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
additional information thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
dithiothreitol
-
 Homo sapiens