Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | Rattus norvegicus | 5-deiodinase activity | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar rats | - |
Rattus norvegicus | - |
isozyme type III | - |
Rattus norvegicus | - |
isozyme type II | - |
Rattus norvegicus | - |
isozyme type I | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pituitary gland | posterior | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00000024 | - |
3,3',5-triiodo-L-thyronine 5-deiodination activity, isozyme type III, posterior pituitary gland | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5-triiodo-L-thyronine + AH2 | best substrate | Rattus norvegicus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | isozyme type III | Rattus norvegicus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | preferred substrate | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | isozyme type III | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5-deiodinase activity | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5-deiodinase activity | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
L-thyroxine + AH2 | preferred substrate | Rattus norvegicus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5'-deiodinase activity | Rattus norvegicus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | isozyme type II | Rattus norvegicus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | isozyme type I | Rattus norvegicus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions | Rattus norvegicus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 7.5 | isozyme type III, 3,3',5-triiodo-L-thyronine 5-deiodinase activity | Rattus norvegicus |