Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3',5'-triiodo-L-thyronine | 75% inhibition at 0.01 mM; substrate inhibition | Lithobates catesbeianus | |
3,3',5,5'-tetraiodo-L-thyronine | 95% substrate inhibition at 0.001 mM | Lithobates catesbeianus | |
3,3',5-triiodo-L-thyronine | substrate inhibition, completely at 0.001 mM | Lithobates catesbeianus | |
3,3'-diiodo-L-thyronine | product inhibition, 82% at 0.001 mM | Lithobates catesbeianus | |
3,5-diiodo-L-thyronine | 75% inhibition of 3,3'-diiodo-L-thyronine formation at 0.001 mM | Lithobates catesbeianus | |
sodium iodate | 95% inhibition at 1 mM | Lithobates catesbeianus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000036 | - |
3,3',5-triiodo-L-thyronine | pH 7.0 | Lithobates catesbeianus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Lithobates catesbeianus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5-triiodo-L-thyronine + AH2 | Lithobates catesbeianus | - |
3,3'-diiodo-L-thyronine + iodide + A + H+ | i.e. 3,3'-diiodo-L-thyronine | ? | |
L-thyroxine + AH2 | Lithobates catesbeianus | 5-deiodinase activity | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Lithobates catesbeianus | in pre- and prometamorphic tadpoles, undetectable during metamorphic climax | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Lithobates catesbeianus | 5'-deiodinase activity | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Lithobates catesbeianus | in vivo after entering metamorphic climax, low 5'-deiodinase activity | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | Lithobates catesbeianus | enzyme activity is developmentally regulated, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Lithobates catesbeianus | - |
isozyme type III | - |
Lithobates catesbeianus | - |
tadpole | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | tadpole | Lithobates catesbeianus | - |
additional information | 5'-deiodinase and 5-deiodinase activity are developmentally regulated | Lithobates catesbeianus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodo-L-thyronine + AH2 | - |
Lithobates catesbeianus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | - |
Lithobates catesbeianus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | i.e. 3,3'-diiodo-L-thyronine | ? | |
3,3',5-triiodo-L-thyronine + AH2 | best substrate | Lithobates catesbeianus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | isozyme type III | Lithobates catesbeianus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5-deiodinase activity | Lithobates catesbeianus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | in pre- and prometamorphic tadpoles, undetectable during metamorphic climax | Lithobates catesbeianus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | low activity | Lithobates catesbeianus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5'-deiodinase activity | Lithobates catesbeianus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | in vivo after entering metamorphic climax, low 5'-deiodinase activity | Lithobates catesbeianus | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | enzyme activity is developmentally regulated, overview | Lithobates catesbeianus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Lithobates catesbeianus |