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Literature summary for 1.21.4.5 extracted from

  • Kiefer, P.M.; McCarthy, D.L.; Copley, S.D.
    The reaction catalyzed by tetrachlorohydroquinone dehalogenase does not involve nucleophilic aromatic substitution (2002), Biochemistry, 41, 1308-1314 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
C13S the mutant enzyme catalyzes only the initial steps in the reaction. In the absence of Cys13, the intermediate 3,5-dichloro-6-S-glutathionyl-4-hydroxycyclohexa-2,4-dienone decomposes to a mixture of products in a pH-dependent fashion Sphingobium chlorophenolicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3,5,6-tetrachlorohydroquinone + 2 glutathione Sphingobium chlorophenolicum the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
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?
2,3,6-trichlorohydroquinone + 2 glutathione Sphingobium chlorophenolicum the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
?

Organism

Organism UniProt Comment Textmining
Sphingobium chlorophenolicum Q03520
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3,5,6-tetrachlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative Sphingobium chlorophenolicum 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
-
?
2,3,5,6-tetrachlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The reaction does not involve nucleophilic aromatic substitution Sphingobium chlorophenolicum 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
-
?
2,3,6-trichlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative Sphingobium chlorophenolicum 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
?
2,3,6-trichlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone Sphingobium chlorophenolicum 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
?

Synonyms

Synonyms Comment Organism
TCHQ dehalogenase
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Sphingobium chlorophenolicum
tetrachlorohydroquinone dehalogenase
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Sphingobium chlorophenolicum