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Literature summary for 1.21.3.7 extracted from

  • Lange, K.; Schmid, A.; Julsing, M.K.
    DELTA9-Tetrahydrocannabinolic acid synthase The application of a plant secondary metabolite enzyme in biocatalytic chemical synthesis (2016), J. Biotechnol., 233, 42-48 .
    View publication on PubMed
Search for more literature for 1.21.3.7

Activating Compound

Activating Compound Comment Organism Structure
BSA the addition of BSA has a slightly positive effect on the activity of the enzyme Cannabis sativa

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris KM71 KE1 cells Cannabis sativa

Inhibitors

Inhibitors Comment Organism Structure
cannabigerolate substrate inhibition Cannabis sativa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0084
-
 cannabigerolate at pH 5.0 and 30°C Cannabis sativa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cannabigerolate + O2 Cannabis sativa
-
 DELTA9-tetrahydrocannabinolate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Cannabis sativa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cannabigerolate + O2
-
 Cannabis sativa DELTA9-tetrahydrocannabinolate + H2O2
-
 ?

Subunits

Subunits Comment Organism
? x * 59000, SDS-PAGE Cannabis sativa

Synonyms

Synonyms Comment Organism
DELTA9-tetrahydrocannabinolic acid synthase
-
 Cannabis sativa
THCAS
-
 Cannabis sativa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.308
-
 cannabigerolate at pH 5.0 and 30°C Cannabis sativa

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Cannabis sativa