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Literature summary for 1.21.3.10 extracted from

  • Pluskal, T.; Ueno, M.; Yanagida, M.
    Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system (2014), PLoS One, 9, e97774.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.21.3.10

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ the enzyme requires Fe2+ for activity Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hercynine + L-cysteine + O2 Schizosaccharomyces pombe the enzyme is part of the biosynthesis pathway of ergothioneine S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hercynine + L-cysteine + O2 the enzyme is part of the biosynthesis pathway of ergothioneine Schizosaccharomyces pombe S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
-
 ?
hercynine + L-cysteine + O2 hercynine i.e. Nalpha,Nalpha,Nalpha-trimethyl-L-histidine Schizosaccharomyces pombe S-(hercyn-2-yl)-L-cysteine S-oxide + H2O
-
 ?
hercynine + L-selenocysteine + O2 hercynine i.e. Nalpha,Nalpha,Nalpha-trimethyl-L-histidine Schizosaccharomyces pombe S-(hercyn-2-yl)-L-selenocysteine S-oxide + H2O
-
 ?

Subunits

Subunits Comment Organism
More the enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nalpha-methyltransferase Schizosaccharomyces pombe

Synonyms

Synonyms Comment Organism
Egt-1
-
 Schizosaccharomyces pombe
Egt1
-
 Schizosaccharomyces pombe

General Information

General Information Comment Organism
malfunction the DELTA egt1 deletion mutant shows a complete absence of ergothioneine and all its precursors Schizosaccharomyces pombe