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Literature summary for 1.21.1.1 extracted from
- Expression of iodotyrosine deiodinase in thyroid and other organs in iodine-deficient and iodine-excess rats (2015), Biol. Trace Elem. Res., 167, 272-279.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| quantitative RT-PCR enzyme expression analysis, overview | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + 2 NADP+ + 2 iodide | Rattus norvegicus | - |
3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ | - |
r |  |
| L-tyrosine + 2 NADP+ + 2 iodide | Rattus norvegicus Wistar | - |
3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
female | - |
| Rattus norvegicus Wistar | - |
female | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| additional information | tissue expression analysis of the enzyme in conditions such as iodine deficiency and excess, overview | Rattus norvegicus | - |
| thyroid | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + 2 NADP+ + 2 iodide | - |
Rattus norvegicus | 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ | - |
r | |
| L-tyrosine + 2 NADP+ + 2 iodide | - |
Rattus norvegicus Wistar | 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IYD | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | a flavin mononucleotide-dependent deiodinase | Rattus norvegicus | |
| NADPH | dependent on | Rattus norvegicus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | the enzyme is suppressed in liver and kidney by iodine intake. Excess iodine decreases the expression of thyroidal enzyme | down |
| Rattus norvegicus | iodine deficiency results in an increased enzyme expression in thyroid | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme, catalyzing the reductive dehalogenation, is a critical enzyme in maintaining iodine homeostasis | Rattus norvegicus |
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Release 2023.1 (January 2023)
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