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Literature summary for 1.21.1.1 extracted from

  • Shimizu, R.
    Iodotyrosine deiodinase, a novel target of environmental halogenated chemicals for disruption of the thyroid hormone system in mammals (2014), Biol. Pharm. Bull., 37, 1430-1434.
    View publication on PubMed
Search for more literature for 1.21.1.1

Application

Application Comment Organism
additional information target for disruption of thyroid hormone homeostasis by environmental halogenated chemicals Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2',3,4',5,6'-pentachlorobiphenyl-4-ol
-
 Homo sapiens
2',3,4',6'-tetrachlorobiphenyl-4-ol
-
 Homo sapiens
2,2',5,5'-tetrachlorobiphenyl-4-ol
-
 Homo sapiens
2,3,6-tribromo-4-(2,4-dibromophenoxy)phenol
-
 Homo sapiens
2,3-dibromo-4-(2,4-dibromophenoxy)phenol
-
 Homo sapiens
2,5-dibromo-4-(2,4-dibromophenoxy)phenol
-
 Homo sapiens
3-bromo-4-(2,4-dibromophenoxy)phenol
-
 Homo sapiens
3-hydroxy-2,2',5,5'-tetrachlorobiphenyl
-
 Homo sapiens
4,4'-dihydroxy-3,3',5,5'-tetrachlorobiphenyl
-
 Homo sapiens
5-bromo-2-(2,4-dibromophenoxy)phenol
-
 Homo sapiens
5-bromo-2-(4-bromophenoxy)phenol
-
 Homo sapiens
benzbromarone
-
 Homo sapiens
bithionol
-
 Homo sapiens
bromoxynil
-
 Homo sapiens
closantel
-
 Homo sapiens
erythrosine B
-
 Homo sapiens
additional information target for disruption of thyroid hormone homeostasis by environmental halogenated chemicals, e.g. food colorants, pharmaceuticals, agrochemicals, and antiparasitics, effects of environmental halogenated chemicals on iodotyrosine deiodinase activity, overview. Non-hydroxylated PCBs (e.g., 2,2',4,4'-tetrachlorobiphenyl) and PBDEs (e.g., 2,2',4,4'-tetrabromodiphenyl ether), nitrofen, trichlabendazole, miconazole and amiodarone lack IYD-inhibitory activity Homo sapiens
nitroxynil
-
 Homo sapiens
oxyclozanide
-
 Homo sapiens
phloxine B
-
 Homo sapiens
Rose bengal
-
 Homo sapiens
tribromsalan
-
 Homo sapiens
triclosan
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + 2 NADP+ + 2 iodide Homo sapiens
-
 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6PHW0 gene DEHAL1
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 2 NADP+ + 2 iodide
-
 Homo sapiens 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
 r
additional information the enzyme can act as a general dehalogenase, promoting reductive dehalogenation of 3-bromo- and 3-chloro-L-tyrosine, though not 3-fluoro-L-tyrosine Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
IYD
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FMN
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction thyroid dysfunction can have very serious consequences, including mental retardation Homo sapiens
physiological function a FMN moiety that is involved in reduced NADPH-dependent reductive deiodination of 3-iodo-Ltyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT), which are released along with the thyroid hormones T4 and T3 during thyroglobulin proteolysis. Iodotyrosine deiodinase is involved in iodide salvage by catalyzing deiodination of iodinated by-products of thyroid hormone production. Thyroid hormones play important roles in growth, development, differentiation, and basal metabolic homeostasis, as well as in brain development in human fetus and children Homo sapiens