Cloned (Comment) | Organism |
---|---|
expression in HEK-293T cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4'-hydroxy-2,2',4,5'-tetrabromodiphenyl ether | - |
Homo sapiens | |
4'-hydroxy-2,2',4-tribromodiphenyl ether | - |
Homo sapiens | |
4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl | - |
Homo sapiens | |
4-hydroxy-2,2',3,4',5-pentabromodiphenyl ether | - |
Homo sapiens | |
4-hydroxy-2,3,3',4'-tetrabromodiphenyl ether | - |
Homo sapiens | |
benzbromarone | - |
Homo sapiens | |
erythrosine B | - |
Homo sapiens | |
additional information | among polychlorinated biphenyls and polybrominated diphenyl ethers without a hydroxyl group tested, including their methoxylated metabolites, none is inhibitory | Homo sapiens | |
phloxine B | - |
Homo sapiens | |
Rose bengal | most potent inhibitor tested | Homo sapiens | |
triclosan | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-iodo-L-tyrosine + NADPH + H+ | - |
Homo sapiens | L-tyrosine + NADP+ + I- | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
pH 7.4, 25°C | Homo sapiens | Rose bengal | |
0.0008 | - |
pH 7.4, 25°C | Homo sapiens | erythrosine B | |
0.0008 | - |
pH 7.4, 25°C | Homo sapiens | phloxine B | |
0.011 | - |
pH 7.4, 25°C | Homo sapiens | benzbromarone | |
0.017 | - |
pH 7.4, 25°C | Homo sapiens | 4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl | |
0.019 | - |
pH 7.4, 25°C | Homo sapiens | triclosan |