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Literature summary for 1.21.1.1 extracted from

  • Shimizu, R.; Yamaguchi, M.; Uramaru, N.; Kuroki, H.; Ohta, S.; Kitamura, S.; Sugihara, K.
    Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity (2013), Toxicology, 314, 22-29.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4'-hydroxy-2,2',4,5'-tetrabromodiphenyl ether
-
Homo sapiens
4'-hydroxy-2,2',4-tribromodiphenyl ether
-
Homo sapiens
4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl
-
Homo sapiens
4-hydroxy-2,2',3,4',5-pentabromodiphenyl ether
-
Homo sapiens
4-hydroxy-2,3,3',4'-tetrabromodiphenyl ether
-
Homo sapiens
benzbromarone
-
Homo sapiens
erythrosine B
-
Homo sapiens
additional information among polychlorinated biphenyls and polybrominated diphenyl ethers without a hydroxyl group tested, including their methoxylated metabolites, none is inhibitory Homo sapiens
phloxine B
-
Homo sapiens
Rose bengal most potent inhibitor tested Homo sapiens
triclosan
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-iodo-L-tyrosine + NADPH + H+
-
Homo sapiens L-tyrosine + NADP+ + I-
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
pH 7.4, 25°C Homo sapiens Rose bengal
0.0008
-
pH 7.4, 25°C Homo sapiens erythrosine B
0.0008
-
pH 7.4, 25°C Homo sapiens phloxine B
0.011
-
pH 7.4, 25°C Homo sapiens benzbromarone
0.017
-
pH 7.4, 25°C Homo sapiens 4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl
0.019
-
pH 7.4, 25°C Homo sapiens triclosan