Protein Variants | Comment | Organism |
---|---|---|
A140D | isoform GSTO2, natural polymorphism, no significant alteration in monomethylarsonate reductase activity | Homo sapiens |
DELTAE155 | isoform GSTO2, natural polymorphism, 90% increase in monomethylarsonate reductase activity | Homo sapiens |
DELTAE155/E208K | isoform GSTO2, natural polymorphism, 100% increase in monomethylarsonate reductase activity, decrease in heat stability | Homo sapiens |
E208K | isoform GSTO2, natural polymorphism, slight increase in monomethylarsonate reductase activity, decrease in heat stability | Homo sapiens |
N142D | isoform GSTO2, natural polymorphism, no significant alteration in monomethylarsonate reductase activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P78417 | isoforms GSTO1, GSTO2 and their natural polymorphisms. Enzyme has additionally thioltransferase, dehydroascorbate reductase and dimethylarsonate reductase activities | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.27 | - |
GSTO1 mutant A140D, 30°C, pH 5.5 | Homo sapiens |
0.33 | - |
wild-type GSTO1, 30°C, pH 5.5 | Homo sapiens |
0.39 | - |
GSTO1 mutant E208K, 30°C, pH 5.5 | Homo sapiens |
0.42 | - |
wild-type GSTO1, 30°C, pH 5.5 | Homo sapiens |
0.44 | - |
GSTO2 mutant N142D, 30°C, pH 5.5 | Homo sapiens |
0.65 | - |
GSTO1 mutant DELTAE155, 30°C, pH 5.5 | Homo sapiens |
0.67 | - |
GSTO1 mutant DELTAE155/E208K, 30°C, pH 5.5 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
monomethylarsonate + glutathione | - |
Homo sapiens | monomethylarsonous acid + oxidized glutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GSTO1 | - |
Homo sapiens |
GSTO2 | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
wild-type, 30 min, 60% residual activity. GSTO1 mutant E208K, 30 min, 80% residual activity, GSTO1 mutant DELTAE155/E208K, 30 min, no residual activity | Homo sapiens |